Novel Insights into the Roles of Migrasome in Cancer

Overview

Journal Discov Oncol

Publisher Springer

Specialty Oncology

Date 2024 May 15

PMID 38748047

Authors

Sijun Deng

Yiwen Wu

Sheng Huang

Xiaoyan Yang

Affiliations

Soon will be listed here.

Abstract

Cell migration, a hallmark of cancer malignancy, plays a critical role in cancers. Improperly initiated or misdirected cell migration can lead to invasive metastatic cancer. Migrasomes are newly discovered vesicular cellular organelles produced by migrating cells and depending on cell migration. Four marker proteins [NDST1 (bifunctionalheparan sulfate N-deacetylase/N-sulfotransferase 1), EOGT (Epidermal growth factor domains pecific O-linked N-acetylglucosaminetransferase), CPQ (carboxypeptidase Q), and PIGK (phosphatidylinositol glycan anchor biosynthesis, class K)] of migrasomes were successfully identified. There are three marker proteins (NDST1, PIGK, and EOGT) of migrasome expressed in cancer. In this review, we will discuss the process of migrasome discovery, the formation of migrasome, the possible functions of migrasome, and the differences between migrasomes and exosomes, especially, the biological functions of migrasome marker proteins in cancer, and discuss some possible roles of migrasomes in cancer. We speculate that migrasomes and migracytosis can play key roles in regulating the development of cancer.

Citing Articles

Research progress of migrasomes: from genesis to formation, physiology to pathology.

Tang H, Huang Z, Wang M, Luan X, Deng Z, Xu J Front Cell Dev Biol. 2024; 12:1420413.

PMID: 39206093 PMC: 11349668. DOI: 10.3389/fcell.2024.1420413.

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