MRNA Cap-binding Protein EIF4E1 is a Novel Regulator of Latency

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 May 15

PMID 38747593

Authors

Michael J Holmes

Matheus S Bastos

Vishakha Dey

Vanessa Severo

Ronald C Wek

William J Sullivan Jr

Affiliations

Soon will be listed here.

Abstract

Importance: is an opportunistic pathogen important to global human and animal health. There are currently no chemotherapies targeting the encysted form of the parasite. Consequently, a better understanding of the mechanisms controlling encystation is required. Here we show that the mRNA cap-binding protein, eIF4E1, regulates the encystation process. Encysted parasites reduce eIF4E1 levels, and depletion of eIF4E1 decreases the translation of ribosome-associated machinery and drives encystation. Together, these data reveal a new layer of mRNA translational control that regulates parasite encystation and latency.

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