A Comparative Evaluation of Error Processing Performance and Its Relationship with Cognitive Function in Patients with Alzheimer's Disease, Individuals with Mild Cognitive Impairment, and Normal Controls Using the Event-Related Potentials

Overview

Journal J Alzheimers Dis Rep

Publisher IOS Press

Date 2024 May 15

PMID 38746624

Authors

Mohammad Hedayatjoo

Mehdi Tehrani-Doost

Zahra Vahabi

Malahat Akbarfahimi

Reza Khosrowabadi

Affiliations

Soon will be listed here.

Abstract

Background: Some pathological changes occur in patients with Alzheimer's disease (AD) prior to the onset of clinical symptoms.

Objective: In the present study, we aimed to investigate the potential of event-related potential (ERP) components in error processing performance as a neuromarker of mild cognitive impairment (MCI) and transition to AD and their relation with cognitive functions.

Methods: We conducted an evaluation of 16 patients diagnosed with AD, 16 patients with MCI, and 15 normal controls using three subtests from the Cambridge Neuropsychological Testing Automated Battery (CANTAB). The ERP components of error processing were extracted and compared among the three groups using a modified version of the Eriksen flanker task. Additionally, we assessed the correlation between the cognitive results and the ERP components.

Results: Significant differences were observed among the three groups in terms of providing correct responses following errors and the amplitude of error-related negativity (ERN). These differences were also significant between all paired groups. Regarding other ERP components of error processing and the peak latency of ERN, no significant differences were observed among the three groups. The findings revealed that the spatial working memory and new learning were correlated with the amplitude of ERN.

Conclusions: In the context of error processing performance, both the accuracy of responses following an error and the amplitude of ERN can be considered as indicators of MCI and its progression to AD. The present findings do not support the use of other error processing components as differential markers in the three groups.

References

Suchan B, Jokisch D, Skotara N, Daum I . Evaluation-related frontocentral negativity evoked by correct responses and errors. Behav Brain Res. 2007; 183(2):206-12. DOI: 10.1016/j.bbr.2007.06.013. View

Horvath A, Szucs A, Csukly G, Sakovics A, Stefanics G, Kamondi A . EEG and ERP biomarkers of Alzheimer's disease: a critical review. Front Biosci (Landmark Ed). 2017; 23(2):183-220. DOI: 10.2741/4587. View

Dhikav V, Anand K . Potential predictors of hippocampal atrophy in Alzheimer's disease. Drugs Aging. 2010; 28(1):1-11. DOI: 10.2165/11586390-000000000-00000. View

Egerhazi A, Berecz R, Bartok E, Degrell I . Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(3):746-51. DOI: 10.1016/j.pnpbp.2007.01.011. View

Thurm F, Antonenko D, Schlee W, Kolassa S, Elbert T, Kolassa I . Effects of aging and mild cognitive impairment on electrophysiological correlates of performance monitoring. J Alzheimers Dis. 2013; 35(3):575-87. DOI: 10.3233/JAD-121348. View

Soares F, Galdino de Oliveira T, de Macedo L, Tomas A, Picanco-Diniz D, Bento-Torres J . CANTAB object recognition and language tests to detect aging cognitive decline: an exploratory comparative study. Clin Interv Aging. 2015; 10:37-48. PMC: 4279672. DOI: 10.2147/CIA.S68186. View

Wessel J . An adaptive orienting theory of error processing. Psychophysiology. 2017; 55(3). DOI: 10.1111/psyp.13041. View

Stretton J, Thompson P . Frontal lobe function in temporal lobe epilepsy. Epilepsy Res. 2011; 98(1):1-13. PMC: 3398387. DOI: 10.1016/j.eplepsyres.2011.10.009. View

Kirova A, Bays R, Lagalwar S . Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer's disease. Biomed Res Int. 2015; 2015:748212. PMC: 4624908. DOI: 10.1155/2015/748212. View

10.

Balbaid N, Al-Dawalibi A, Khattab A, Al-Saqr F, AbuSittah A, Alqarni S . The Relationship between Cognitive Impairment and Coronary Artery Disease in Middle-aged Adults. Cureus. 2020; 12(1):e6724. PMC: 7034738. DOI: 10.7759/cureus.6724. View

11.

Coleman J, Watson J, Strayer D . Working memory capacity and task goals modulate error-related ERPs. Psychophysiology. 2017; 55(3). DOI: 10.1111/psyp.12805. View

12.

Stemmer B, Segalowitz S, Witzke W, Schonle P . Error detection in patients with lesions to the medial prefrontal cortex: an ERP study. Neuropsychologia. 2003; 42(1):118-30. DOI: 10.1016/s0028-3932(03)00121-0. View

13.

Arevalo-Rodriguez I, Smailagic N, Roque I Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A . Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2015; (3):CD010783. PMC: 6464748. DOI: 10.1002/14651858.CD010783.pub2. View

14.

Joseph S, Knezevic D, Zomorrodi R, Blumberger D, Daskalakis Z, Mulsant B . Dorsolateral prefrontal cortex excitability abnormalities in Alzheimer's Dementia: Findings from transcranial magnetic stimulation and electroencephalography study. Int J Psychophysiol. 2021; 169:55-62. DOI: 10.1016/j.ijpsycho.2021.08.008. View

15.

Olvet D, Hajcak G . Reliability of error-related brain activity. Brain Res. 2009; 1284:89-99. DOI: 10.1016/j.brainres.2009.05.079. View

16.

Ito J, Kitagawa J . Error processing in patients with Alzheimer's disease. Pathophysiology. 2005; 12(2):97-101. DOI: 10.1016/j.pathophys.2005.02.003. View

17.

Yousefzadeh Chabok S, Kapourchali S, Leili E, Saberi A, Mohtasham-Amiri Z . Effective factors on linguistic disorder during acute phase following traumatic brain injury in adults. Neuropsychologia. 2012; 50(7):1444-50. DOI: 10.1016/j.neuropsychologia.2012.02.029. View

18.

Mathalon D, Jorgensen K, Roach B, Ford J . Error detection failures in schizophrenia: ERPs and FMRI. Int J Psychophysiol. 2009; 73(2):109-17. PMC: 4005823. DOI: 10.1016/j.ijpsycho.2009.02.005. View

19.

Mathalon D, Bennett A, Askari N, Gray E, Rosenbloom M, Ford J . Response-monitoring dysfunction in aging and Alzheimer's disease: an event-related potential study. Neurobiol Aging. 2003; 24(5):675-85. DOI: 10.1016/s0197-4580(02)00154-9. View

20.

van Schie H, Mars R, Coles M, Bekkering H . Modulation of activity in medial frontal and motor cortices during error observation. Nat Neurosci. 2004; 7(5):549-54. DOI: 10.1038/nn1239. View