Are Adipokines Related to COVID-19 and Its Severity? A Systematic Review and Meta-analysis

Overview

Journal Med Pharm Rep

Specialty General Medicine

Date 2024 May 15

PMID 38746027

Authors

Abdulrahman Ismaiel

Louis Birkhahn

Daniel-Corneliu Leucuta

Nahlah Al Srouji

Stefan-Lucian Popa

Dan L Dumitrascu

Affiliations

Soon will be listed here.

Abstract

Introduction: The relationship between several adipokines and COVID-19 severity has lately been evaluated, results being inconclusive. Therefore, we aimed to assess the association between adipokines in COVID-19 and its severity.

Methods: A search was performed in PubMed, Scopus, and Embase using predefined keywords. The Newcastle of Ottawa Scale (NOS) was used for the quality assessment of included studies. The main summary outcome was the mean difference (MD) in adipokine levels.

Results: A total of 8 studies involving 473 individuals were included. A significant MD in serum adiponectin levels was demonstrated in mild vs. severe COVID-19 patients (-5.734 [95% CI -11.215 - -0.252]), with no significant MD in mild vs. moderate (-7.117 [95% CI -19.546 - 5.313]), or moderate vs. severe COVID-19 (-1.846 [95% CI -4.516 - 0.824]). Moreover, no significant MD was found in adiponectin and leptin levels when comparing COVID-19 patients vs. controls (-12.675 [95% CI -36.159 - 10.808]) and (8.034 [95% CI -10.403 - 26.471]), respectively.

Conclusion: Adiponectin levels were significantly increased in patients with severe compared to mild COVID-19. However, no significant MD was found in adiponectin levels in mild vs. moderate and moderate vs. severe COVID-19 patients, nor in adiponectin and leptin levels in COVID-19 patients vs. controls.

Citing Articles

Circulating levels of adiponectin and AdipoR expression in peripheral blood mononuclear cells are associated with lower respiratory tract Infection.

Wang Q, Wang X, Xu D, Jiang M, Gao Y, Jiang L Front Immunol. 2025; 15:1510760.

PMID: 39840070 PMC: 11746025. DOI: 10.3389/fimmu.2024.1510760.

Changes in Circulating Adipokine Levels in COVID-19 Patients.

Wikar T, Rubinkiewicz M, Stygar D, Chelmecka E, Popiela U, Michal W J Clin Med. 2024; 13(16).

PMID: 39200926 PMC: 11355170. DOI: 10.3390/jcm13164784.

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