Impact of Bariatric Surgery on Circulating Irisin Levels: a Systematic Review and Meta‑analysis

Overview

Journal Updates Surg

Specialty General Surgery

Date 2024 May 14

PMID 38743243

Authors

Tannaz Jamialahamdi

Elaheh Mirhadi

Wael Almahmeed

Ali H Eid

Khalid Al-Rasadi

Ninh T Nguyen

Kishore M Gadde

Amirhossein Sahebkar

Affiliations

Soon will be listed here.

Abstract

This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was depicted through a random-effects meta-analysis and the leave-one-out method. The meta-analysis, which included 13 studies with a total of 407 participants, showed a statistically non-significant reduction in circulating irisin levels following bariatric surgery (SMD: - 0.089, 95% CI - 0.281, 0.102, 95% PI: - 0.790, 0.611, p = 0.360; I:70.56). Our research found no significant change in irisin levels after bariatric surgery. Moreover, these findings were not associated with the type of surgery or the duration of follow-up.

Citing Articles

Serum Irisin, Myostatin, and Myonectin Correlate with Metabolic Health Markers, Liver Disease Progression, and Blood Pressure in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease and Hypertension.

Sheptulina A, Mamutova E, Elkina A, Timofeev Y, Metelskaya V, Kiselev A Metabolites. 2024; 14(11).

PMID: 39590820 PMC: 11596689. DOI: 10.3390/metabo14110584.

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