Sex Differences and Risk Factors of Self-reported Suicide Attempts in Middle-aged Chinese Han Patients with First-episode Drug-naïve Anxious Depression: a Large-scale Cross-sectional Study

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2024 May 14

PMID 38743092

Authors

Guoshuai Luo

Shuo Wang

Lei Gou

Cui Li

Cong Yao

Yifan Jing

Zaimina Xuekelaiti

Jie Li

Xiang-Yang Zhang

Affiliations

Soon will be listed here.

Abstract

This study aims to investigate sex differences and risk factors for self-reported suicide attempts among Chinese Han middle-aged patients with first-episode drug-naïve (FEDN) anxious depression (AD). A total of 1796 patients with FEDN major depressive disorder were enrolled in this study, including 341 middle-aged patients with AD. We compared the prevalence, demographics, and clinical characteristics of suicide attempts between male and female patients with FEDN middle-aged AD. We also explored the risk factors for self-reported suicide attempts in this population using binary logistic regression analysis. The male/female ratio was 91/250 and the age of onset was 51.50 ± 4.13. Our results showed that there were no significant sex differences in the prevalence of self-reported suicide attempts in middle-aged patients with FEDN AD. However, we did find significant differences in several demographic and clinical characteristics between self-reported suicide attempters and non-suicide attempters. Moreover, severe anxiety, measured by the Hamilton Anxiety Rating Scale score, was identified as a risk factor for self-reported suicide attempts in female middle-aged AD patients. Additionally, elevated thyroid peroxidase antibody (TPOAb) levels were linked to self-reported suicide attempts in male AD patients. Our findings suggest that there are no significant sex differences in the prevalence of self-reported suicide attempts in this population, but there may be sex-specific risk factors for self-reported suicide attempts in middle-aged AD. Clinical psychiatrists need to pay attention to thyroid hormone levels in middle-aged anxious depression.

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