Short-term Effects of Nitrogen Dioxide on Inpatient Acute Myocardial Infarction in Lanzhou, China

Nitrogen dioxide (NO) represents a deleterious effect on acute myocardial infarction (AMI), but few relevant studies have been conducted in China. We aim to evaluate the acute effects of NO exposure on hospitalization for AMI in Lanzhou, China. In this study, we applied a distributional lag nonlinear model (DLNM) to assess the association between NO exposure and AMI hospitalization. We explored the sensitivity of various groups through stratified analysis by gender, age, and season. The daily average concentration of NO is 47.50 ± 17.38 µg/m. We observed a significant exposure-response relationship between NO2 concentration and AMI hospitalization. The single pollutant model analysis shows that NO is positively correlated with AMI hospitalization at lag1, lag01, lag02, and lag03. The greatest lag effect estimate occurs at lag01, where a 10 µg/m increase in NO concentrations is significantly associated with a relative risk (RR) of hospitalization due to AMI of 1.027 [95% confidence interval (CI): 1.013, 1.042]. The results of the stratified analysis by gender, age, and season indicate that males, those aged ≥65 years, and the cold season are more sensitive to the deleterious effects caused by NO exposure. Short-term exposure to NO can enhance the risk of AMI hospitalization in urban Lanzhou.: Exposure to particulate matter can lead to an increased incidence of AMI. Our study once again shows that NO exposure increases the risk of AMI hospital admission. AMI is a common and expensive fatal condition. Reducing NO exposure will benefit cardiovascular health and save on healthcare costs.