Pleural Epithelioid Hemangioendothelioma: An Ultrarare Cause for Recurrent Pleural Effusion Managed With Trametinib and Pazopanib

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 May 13

PMID 38736758

Authors

Ali Khreisat

Paul Bozyk

Gloria Hong

Casey P Schukow

Affiliations

Soon will be listed here.

Abstract

Epithelioid hemangioendothelioma (EHE) is an extremely rare sarcoma of vascular origin. Primary pleural involvement is extremely under-reported and tends to have a more aggressive course. We report a case of pleural EHE in a Caucasian female in her 50s with a two-month history of dyspnea and chest pain. Investigations, including video-assisted thoracoscopy, revealed extensive pleural scarring and inflammation. Management with trametinib and pazopanib led to a stable disease course, reduction in the frequency of pleural effusion recurrence, and improvement in cancer-related pain.

Citing Articles

Rare cancer with primary pleural epithelioid hemangioendothelioma diagnosed by thoracoscopic biopsy achieving disease control after 16 months: case report and literature review.

Pateras I, Kostopanagiotou K, Samaras M, Koumarianou A, Koutrouli M, Korodimos N Front Pharmacol. 2024; 15:1482154.

PMID: 39650162 PMC: 11621942. DOI: 10.3389/fphar.2024.1482154.

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