Association Between ACE2 and Lung Diseases

Overview

Journal Infect Drug Resist

Publisher Dove Medical Press

Date 2024 May 13

PMID 38736435

Authors

Cheng Su

Cai Li

Xinyi Hu

Jing Wang

Linlin Liu

Xianfeng Zhang

Yeqing Tong

Affiliations

Soon will be listed here.

Abstract

Angiotensin-converting enzyme 2 (ACE2) is an important regulator of the Renin-Angiotensin System (RAS). Additionally, it has been identified as a functional receptor for the Coronavirus. Research indicates that ACE2 plays a role in the regulation of cardiovascular systems by modulating blood pressure and electrolyte balance. Its role in pulmonary diseases has also garnered significant attention due to the widespread prevalence of Coronavirus. There is solid evidence linking ACE2 to other pulmonary diseases, including chronic obstructive pulmonary disease, acute respiratory distress syndrome, allergic asthma, among others. However, the exact pathological and physiological mechanisms of ACE2 in these diseases remain elusive. Our research aims to review and explore the latest advancements in ACE2-related studies in pulmonary diseases. These findings have the potential to open new avenues for utilizing ACE2 as a potential biomarker for early diagnosis and monitoring of pulmonary diseases.

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