Advancements in Polymer-Assisted Layer-by-Layer Fabrication of Wearable Sensors for Health Monitoring

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2024 May 11

PMID 38733009

Authors

Meiqing Jin

Peizheng Shi

Zhuang Sun

Ningbin Zhao

Mingjiao Shi

Mengfan Wu

Chen Ye

Cheng-Te Lin

Li Fu

Affiliations

Soon will be listed here.

Abstract

Recent advancements in polymer-assisted layer-by-layer (LbL) fabrication have revolutionized the development of wearable sensors for health monitoring. LbL self-assembly has emerged as a powerful and versatile technique for creating conformal, flexible, and multi-functional films on various substrates, making it particularly suitable for fabricating wearable sensors. The incorporation of polymers, both natural and synthetic, has played a crucial role in enhancing the performance, stability, and biocompatibility of these sensors. This review provides a comprehensive overview of the principles of LbL self-assembly, the role of polymers in sensor fabrication, and the various types of LbL-fabricated wearable sensors for physical, chemical, and biological sensing. The applications of these sensors in continuous health monitoring, disease diagnosis, and management are discussed in detail, highlighting their potential to revolutionize personalized healthcare. Despite significant progress, challenges related to long-term stability, biocompatibility, data acquisition, and large-scale manufacturing are still to be addressed, providing insights into future research directions. With continued advancements in polymer-assisted LbL fabrication and related fields, wearable sensors are poised to improve the quality of life for individuals worldwide.

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References

Boe A, McGee Koch L, OBrien M, Shawen N, Rogers J, Lieber R . Automating sleep stage classification using wireless, wearable sensors. NPJ Digit Med. 2019; 2:131. PMC: 6925191. DOI: 10.1038/s41746-019-0210-1. View

Lu R, Li W, Katzir A, Raichlin Y, Yu H, Mizaikoff B . Probing the secondary structure of bovine serum albumin during heat-induced denaturation using mid-infrared fiberoptic sensors. Analyst. 2014; 140(3):765-70. DOI: 10.1039/c4an01495b. View

Wong J, Muller C, Laschewsky A, Richtering W . Direct evidence of layer-by-layer assembly of polyelectrolyte multilayers on soft and porous temperature-sensitive PNiPAM microgel using fluorescence correlation spectroscopy. J Phys Chem B. 2007; 111(29):8527-31. DOI: 10.1021/jp0687145. View

Huang C, Fang G, Zhao Y, Bhagia S, Meng X, Yong Q . Bio-inspired nanocomposite by layer-by-layer coating of chitosan/hyaluronic acid multilayers on a hard nanocellulose-hydroxyapatite matrix. Carbohydr Polym. 2019; 222:115036. DOI: 10.1016/j.carbpol.2019.115036. View

Akiba U, Minaki D, Anzai J . Photosensitive Layer-by-Layer Assemblies Containing Azobenzene Groups: Synthesis and Biomedical Applications. Polymers (Basel). 2019; 9(11). PMC: 6418643. DOI: 10.3390/polym9110553. View

Cho S, Lewis E, Zacharia N, Vogt B . Non-destructive determination of functionalized polyelectrolyte placement in layer-by-layer films by IR ellipsometry. Soft Matter. 2021; 17(46):10527-10535. DOI: 10.1039/d1sm01246k. View

Majumder S, Mondal T, Deen M . Wearable Sensors for Remote Health Monitoring. Sensors (Basel). 2017; 17(1). PMC: 5298703. DOI: 10.3390/s17010130. View

Campos P, Dunne A, Delaney C, Moloney C, Moulton S, Benito-Lopez F . Photoswitchable Layer-by-Layer Coatings Based on Photochromic Polynorbornenes Bearing Spiropyran Side Groups. Langmuir. 2018; 34(14):4210-4216. DOI: 10.1021/acs.langmuir.8b00137. View

Govindharajulu J, Chen X, Li Y, Rodriguez-Cabello J, Battacharya M, Aparicio C . Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants. Int J Mol Sci. 2017; 18(2). PMC: 5343904. DOI: 10.3390/ijms18020369. View

10.

Lu Y, Wu Y, Liang J, Libera M, Sukhishvili S . Self-defensive antibacterial layer-by-layer hydrogel coatings with pH-triggered hydrophobicity. Biomaterials. 2015; 45:64-71. DOI: 10.1016/j.biomaterials.2014.12.048. View

11.

Zhang H, Zhang D, Zhang B, Wang D, Tang M . Wearable Pressure Sensor Array with Layer-by-Layer Assembled MXene Nanosheets/Ag Nanoflowers for Motion Monitoring and Human-Machine Interfaces. ACS Appl Mater Interfaces. 2022; 14(43):48907-48916. DOI: 10.1021/acsami.2c14863. View

12.

Huang J, Wang J, Ramsey E, Leavey G, Chico T, Condell J . Applying Artificial Intelligence to Wearable Sensor Data to Diagnose and Predict Cardiovascular Disease: A Review. Sensors (Basel). 2022; 22(20). PMC: 9610988. DOI: 10.3390/s22208002. View

13.

Borges J, Mano J . Molecular interactions driving the layer-by-layer assembly of multilayers. Chem Rev. 2014; 114(18):8883-942. DOI: 10.1021/cr400531v. View

14.

Ai H . Layer-by-layer capsules for magnetic resonance imaging and drug delivery. Adv Drug Deliv Rev. 2011; 63(9):772-88. DOI: 10.1016/j.addr.2011.03.013. View

15.

Guzman E, Mateos-Maroto A, Ruano M, Ortega F, Rubio R . Layer-by-Layer polyelectrolyte assemblies for encapsulation and release of active compounds. Adv Colloid Interface Sci. 2017; 249:290-307. DOI: 10.1016/j.cis.2017.04.009. View

16.

Zhang S, Xia F, Demoustier-Champagne S, Jonas A . Layer-by-layer assembly in nanochannels: assembly mechanism and applications. Nanoscale. 2021; 13(16):7471-7497. DOI: 10.1039/d1nr01113h. View

17.

Zhang S, Abu Zahed M, Sharifuzzaman M, Yoon S, Hui X, Barman S . A wearable battery-free wireless and skin-interfaced microfluidics integrated electrochemical sensing patch for on-site biomarkers monitoring in human perspiration. Biosens Bioelectron. 2020; 175:112844. DOI: 10.1016/j.bios.2020.112844. View

18.

Yang M, Sun N, Lai X, Wu J, Wu L, Zhao X . Paper-Based Sandwich-Structured Wearable Sensor with Sebum Filtering for Continuous Detection of Sweat pH. ACS Sens. 2023; 8(1):176-186. DOI: 10.1021/acssensors.2c02016. View

19.

Wang W, Xu Y, Backes S, Li A, Micciulla S, Kayitmazer A . Construction of Compact Polyelectrolyte Multilayers Inspired by Marine Mussel: Effects of Salt Concentration and pH As Observed by QCM-D and AFM. Langmuir. 2016; 32(14):3365-74. DOI: 10.1021/acs.langmuir.5b04706. View

20.

Lee S, Kang T, Lee S, Lee K, Yi H . Hydrodynamic Layer-by-Layer Assembly of Transferable Enzymatic Conductive Nanonetworks for Enzyme-Sticker-Based Contact Printing of Electrochemical Biosensors. ACS Appl Mater Interfaces. 2018; 10(42):36267-36274. DOI: 10.1021/acsami.8b13070. View