Faecal Volatile Organic Compound Analysis in De Novo Paediatric Inflammatory Bowel Disease by Gas Chromatography-Ion Mobility Spectrometry: A Case-Control Study

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2024 May 11

PMID 38732837

Authors

Eva Vermeer

Jasmijn Z Jagt

Trenton K Stewart

James A Covington

Eduard A Struys

Robert de Jonge

Nanne K H de Boer

Tim G J de Meij

Affiliations

Soon will be listed here.

Abstract

The gut microbiota and its related metabolites differ between inflammatory bowel disease (IBD) patients and healthy controls. In this study, we compared faecal volatile organic compound (VOC) patterns of paediatric IBD patients and controls with gastrointestinal symptoms (CGIs). Additionally, we aimed to assess if baseline VOC profiles could predict treatment response in paediatric IBD patients. We collected faecal samples from a cohort of de novo therapy-naïve paediatric IBD patients and CGIs. VOCs were analysed using gas chromatography-ion mobility spectrometry (GC-IMS). Response was defined as a combination of clinical response based on disease activity scores, without requiring treatment escalation. We included 109 paediatric IBD patients and 75 CGIs, aged 4 to 17 years. Faecal VOC profiles of paediatric IBD patients were distinguishable from those of CGIs (AUC ± 95% CI, -values: 0.71 (0.64-0.79), <0.001). This discrimination was observed in both Crohn's disease (CD) (0.75 (0.67-0.84), <0.001) and ulcerative colitis (UC) (0.67 (0.56-0.78), 0.01) patients. VOC profiles between CD and UC patients were not distinguishable (0.57 (0.45-0.69), 0.87). Baseline VOC profiles of responders did not differ from non-responders (0.70 (0.58-0.83), 0.1). In conclusion, faecal VOC profiles of paediatric IBD patients differ significantly from those of CGIs.

Citing Articles

Gas Chromatography-Sensor System Aids Diagnosis of Inflammatory Bowel Disease, and Separates Crohn's from Ulcerative Colitis, in Children.

Slater R, Tharmaratnam K, Belnour S, Karl-Heinz Auth M, Muhammed R, Spray C Sensors (Basel). 2024; 24(15).

PMID: 39124126 PMC: 11314755. DOI: 10.3390/s24155079.

Wake up and smell the coffee: The potential of faecal volatile organic compounds in paediatric inflammatory bowel disease.

Vermeer E, de Boer N, de Meij T United European Gastroenterol J. 2024; 12(6):660-661.

PMID: 38888204 PMC: 11249820. DOI: 10.1002/ueg2.12618.

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