The Benefits of the Mediterranean Diet on Inflamm-Aging in Childhood Obesity

Overview

Journal Nutrients

Date 2024 May 11

PMID 38732533

Authors

Valeria Calcaterra

Elvira Verduci

Chiara Milanta

Marta Agostinelli

Federica Bona

Stefania Croce

Chiara Valsecchi

Maria Antonietta Avanzini

Gianvincenzo Zuccotti

Affiliations

Soon will be listed here.

Abstract

(1) Background: Numerous elements of the Mediterranean diet (MD) have antioxidant and anti-inflammatory qualities. (2) Methods: We present a narrative review of the potential benefits of the Mediterranean dietary pattern (MD) in mitigating aging-related inflammation (inflamm-aging) associated with childhood obesity. The mechanisms underlying chronic inflammation in obesity are also discussed. A total of 130 papers were included after screening abstracts and full texts. (3) Results: A complex interplay between obesity, chronic inflammation, and related comorbidities is documented. The MD emerges as a promising dietary pattern for mitigating inflammation. Studies suggest that the MD may contribute to weight control, improved lipid profiles, insulin sensitivity, and endothelial function, thereby reducing the risk of metabolic syndrome in children and adolescents with obesity. (4) Conclusions: While evidence supporting the anti-inflammatory effects of the MD in pediatric obesity is still evolving, the existing literature underscores its potential as a preventive and therapeutic strategy. However, MD adherence remains low among children and adolescents, necessitating targeted interventions to promote healthier dietary habits. Future high-quality intervention studies are necessary to elucidate the specific impact of the MD on inflammation in diverse pediatric populations with obesity and associated comorbidities.

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References

Muscogiuri G, Verde L, Sulu C, Katsiki N, Hassapidou M, Frias-Toral E . Mediterranean Diet and Obesity-related Disorders: What is the Evidence?. Curr Obes Rep. 2022; 11(4):287-304. PMC: 9729142. DOI: 10.1007/s13679-022-00481-1. View

Wozniak S, Gee L, Wachtel M, Frezza E . Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci. 2008; 54(9):1847-56. DOI: 10.1007/s10620-008-0585-3. View

Weiss S . Obesity: insight into the origins of asthma. Nat Immunol. 2005; 6(6):537-9. DOI: 10.1038/ni0605-537. View

Lopez-Gil J, Garcia-Hermoso A, Sotos-Prieto M, Cavero-Redondo I, Martinez-Vizcaino V, Kales S . Mediterranean Diet-Based Interventions to Improve Anthropometric and Obesity Indicators in Children and Adolescents: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2023; 14(4):858-869. PMC: 10334150. DOI: 10.1016/j.advnut.2023.04.011. View

Kanellopoulou A, Giannakopoulou S, Notara V, Antonogeorgos G, Rojas-Gil A, Kornilaki E . The association between adherence to the Mediterranean diet and childhood obesity; the role of family structure: Results from an epidemiological study in 1728 Greek students. Nutr Health. 2020; 27(1):39-47. DOI: 10.1177/0260106020952600. View

Wu D, Lewis E, Pae M, Meydani S . Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance. Front Immunol. 2019; 9:3160. PMC: 6340979. DOI: 10.3389/fimmu.2018.03160. View

Bonaccio M, Cerletti C, Iacoviello L, de Gaetano G . Mediterranean diet and low-grade subclinical inflammation: the Moli-sani study. Endocr Metab Immune Disord Drug Targets. 2014; 15(1):18-24. DOI: 10.2174/1871530314666141020112146. View

Ruff W, Greiling T, Kriegel M . Host-microbiota interactions in immune-mediated diseases. Nat Rev Microbiol. 2020; 18(9):521-538. DOI: 10.1038/s41579-020-0367-2. View

Gantenbein K, Kanaka-Gantenbein C . Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing. Nutrients. 2021; 13(6). PMC: 8227318. DOI: 10.3390/nu13061951. View

10.

Schelbert K . Comorbidities of obesity. Prim Care. 2009; 36(2):271-85. DOI: 10.1016/j.pop.2009.01.009. View

11.

Notario-Barandiaran L, Valera-Gran D, Gonzalez-Palacios S, Garcia-de-la-Hera M, Fernandez-Barres S, Pereda-Pereda E . High adherence to a mediterranean diet at age 4 reduces overweight, obesity and abdominal obesity incidence in children at the age of 8. Int J Obes (Lond). 2020; 44(9):1906-1917. DOI: 10.1038/s41366-020-0557-z. View

12.

De Santi M, Callari F, Brandi G, Toscano R, Scarlata L, Amagliani G . Mediterranean diet adherence and weight status among Sicilian Middle school adolescents. Int J Food Sci Nutr. 2020; 71(8):1010-1018. DOI: 10.1080/09637486.2020.1751089. View

13.

Aggarwal B, Sung B . The relationship between inflammation and cancer is analogous to that between fuel and fire. Oncology (Williston Park). 2011; 25(5):414-8. View

14.

Fulop T, Witkowski J, Olivieri F, Larbi A . The integration of inflammaging in age-related diseases. Semin Immunol. 2018; 40:17-35. DOI: 10.1016/j.smim.2018.09.003. View

15.

Lai C, Wu Y, Yu S, Yu Y, Lee S, Liu C . Modulated expression of human peripheral blood microRNAs from infancy to adulthood and its role in aging. Aging Cell. 2014; 13(4):679-89. PMC: 4326935. DOI: 10.1111/acel.12225. View

16.

Heath J, Grant M . The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence. Cells. 2020; 9(3). PMC: 7140628. DOI: 10.3390/cells9030766. View

17.

Lukacova I, Ambro L, Dubayova K, Marekova M . The gut microbiota, its relationship to the immune system, and possibilities of its modulation. Epidemiol Mikrobiol Imunol. 2023; 72(1):40-53. View

18.

Trichopoulou A, Costacou T, Bamia C, Trichopoulos D . Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003; 348(26):2599-608. DOI: 10.1056/NEJMoa025039. View

19.

Colombini B, Dinu M, Murgo E, Lotti S, Tarquini R, Sofi F . Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock. Antioxidants (Basel). 2022; 11(11). PMC: 9686908. DOI: 10.3390/antiox11112228. View

20.

Saavedra D, Ane-Kouri A, Barzilai N, Caruso C, Cho K, Fontana L . Aging and chronic inflammation: highlights from a multidisciplinary workshop. Immun Ageing. 2023; 20(1):25. PMC: 10248980. DOI: 10.1186/s12979-023-00352-w. View