The Immune Response of , , and Genes in the Pathogenesis of COVID-19

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 May 11

PMID 38731851

Authors

Malena Gajate-Arenas

Ingrid Fricke-Galindo

Omar Garcia-Perez

Angelica Dominguez-de-Barros

Gloria Perez-Rubio

Roberto Dorta-Guerra

Ivette Buendia-Roldan

Leslie Chavez-Galan

Jacob Lorenzo-Morales

Ramces Falfan-Valencia

Elizabeth Cordoba-Lanus

Affiliations

Soon will be listed here.

Abstract

COVID-19 is characterized by a wide range of clinical manifestations, where aging, underlying diseases, and genetic background are related to worse outcomes. In the present study, the differential expression of seven genes related to immunity, , , , , , , and , was analyzed in individuals with COVID-19 diagnoses of different disease severities. Two-step RT-qPCR was performed to determine the relative gene expression in whole-blood samples from 160 individuals. The expression of ( < 0.05) and ( < 0.05) was higher in moderate hospitalized cases than in severe ones. Increased gene expression of (OR = 0.64, CI = 0.52-0.79; = 0.001), (OR = 0.581, CI = 0.43-0.79; = 0.001), and (OR = 0.544, CI = 0.39-0.69; < 0.001) was associated with a lower risk of requiring IMV. Moreover, (OR = 0.646, CI = 0.50-0.83; = 0.001), (OR = 0.57, CI = 0.39-0.83; = 0.003), (OR = 0.80, CI = 0.653-0.979; = 0.03), and (OR = 0.827, CI = 0.69-0.991; = 0.039) expression was associated with patient survival. In conclusion, the relevance of , , and in controlling the viral infection was confirmed.

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