Efficient Functionalization of Organosulfones Via Photoredox Catalysis: Direct Incorporation of -Carbonyl Alkyl Side Chains into -Allyl--Ketosulfones

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 May 11

PMID 38731462

Authors

Hong-Li Huang

Shan Li

Yong-Zheng Lv

Ya-Qian Shi

Tian-Tian Pang

Ru-Fen Zhang

Wenjing Huang

Jianhui Yin

Fei Gao

Affiliations

Soon will be listed here.

Abstract

A novel and efficient method for functionalizing organosulfones has been established, utilizing a visible-light-driven intermolecular radical cascade cyclization of -allyl--ketosulfones. This process employs -Ir(ppy) as the photoredox catalyst and -carbonyl alkyl bromide as the oxidizing agent. Via this approach, the substrates experience intermolecular addition of -carbonyl alkyl radicals to the alkene bonds, initiating a sequence of C-C bond formations that culminate in the production of organosulfone derivatives. Notably, this technique features gentle reaction conditions and an exceptional compatibility with a wide array of functional groups, making it a versatile and valuable addition to the field of organic synthesis.

Citing Articles

Recent Advances in the Synthesis of Cyclic Sulfone Compounds with Potential Biological Activity.

Huang H, Shi Y, Ning J, Li S, Song D, Gao F Molecules. 2025; 29(24.

PMID: 39769957 PMC: 11678439. DOI: 10.3390/molecules29245868.

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