» Articles » PMID: 38731112

The Relationship Between Tumor Budding and Tumor Deposits in Patients with Stage III Colorectal Carcinoma

Overview
Journal J Clin Med
Specialty General Medicine
Date 2024 May 11
PMID 38731112
Authors
Affiliations
Soon will be listed here.
Abstract

Recently, some new morphological features of colorectal cancer have been discovered as important prognostic factors; in this paper, we study the relationship between tumor budding (TB) and tumor deposits (TDs). The retrospective cohort study included 90 patients with pathohistologically confirmed stage III CRC who were treated with radical surgical resection. All hematoxylin and eosin (H and E)-stained slides from each patient were reviewed, and histological parameters were recorded. The samples were divided into two groups with similar sizes: a group without TDs (N = 51) and a control group with TDs (N = 39). The presence and TB grade were further analyzed in these groups and compared with other clinical and histological features. The prevalence of TB in the investigated cohort was unexpectedly high (94.4%). Overall, there were 23 (25.6%) Bd1, 20 (22.2%) Bd2, and 47 (52.2%) Bd3 cases. The presence of TDs was significantly associated with a higher number of TB ( < 0.001, OR 16.3) and, consequently, with a higher TB grade ( = 0.004, OR 11.04). A higher TB grade ( = 0.001, HR 2.28; 95% CI 1.93-4.76) and a growing number of TDs ( = 0.014, HR 1.52; 95% CI 1.09-2.1) were statistically significantly associated with shorter survival. TDs appear more often in patients with higher TB grades in stage III CRC. A higher TB grade and a growing number of TDs were statistically significantly associated with shorter overall survival. These results could give additional emphasis to the importance of TB as an adverse prognostic factor since a strong relationship with TDs has been demonstrated.

References
1.
Shinto E, Mochizuki H, Ueno H, Matsubara O, Jass J . A novel classification of tumour budding in colorectal cancer based on the presence of cytoplasmic pseudo-fragments around budding foci. Histopathology. 2005; 47(1):25-31. DOI: 10.1111/j.1365-2559.2005.02162.x. View

2.
Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A . Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3):209-249. DOI: 10.3322/caac.21660. View

3.
Nagtegaal I, Quirke P . Colorectal tumour deposits in the mesorectum and pericolon; a critical review. Histopathology. 2007; 51(2):141-9. DOI: 10.1111/j.1365-2559.2007.02720.x. View

4.
Prabhudesai A, Arif S, Finlayson C, Kumar D . Impact of microscopic extranodal tumor deposits on the outcome of patients with rectal cancer. Dis Colon Rectum. 2003; 46(11):1531-7. DOI: 10.1007/s10350-004-6809-5. View

5.
Ueno H, Murphy J, Jass J, Mochizuki H, Talbot I . Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology. 2002; 40(2):127-32. DOI: 10.1046/j.1365-2559.2002.01324.x. View