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Laparoscopic Treatment of Bulky Nodes in Primary and Recurrent Ovarian Cancer: Surgical Technique and Outcomes from Two Specialized Italian Centers

Overview
Journal Cancers (Basel)
Publisher MDPI
Specialty Oncology
Date 2024 May 11
PMID 38730583
Authors
Affiliations
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Abstract

(1) Background: Minimally invasive surgery (MIS) represents a feasible approach in early-stage ovarian cancer, while this question is still unsolved for advanced and recurrent disease. (2) Methods: In this retrospective, multicenter study, we present a series of 21 patients who underwent MIS for primitive or recurrent epithelial ovarian cancer (EOC) with bulky nodal metastasis and discuss surgical technique and outcomes in relation to the current literature. (3) Results: Complete cytoreduction at primary debulking surgery was obtained in 86% of cases. No complication occurred in our patients intraoperatively and only 11.1% of our patients experienced grade 2 and 3 postoperative complications. Notably, all the patients with isolated lymph nodal recurrence (ILNR) were successfully treated with a minimally invasive approach with no intra- or postoperative complications. (4) Conclusions: The results of our study are consistent with those reported in the literature, demonstrating that MIS may represent a safe approach in advanced and recurrent EOC with nodal metastasis if performed on selected patients by expert surgeons with an adequate setting and appropriate technique.

References
1.
Ceccaroni M, Roviglione G, Bruni F, Clarizia R, Ruffo G, Salgarello M . Laparoscopy for primary cytoreduction with multivisceral resections in advanced ovarian cancer: prospective validation. "The times they are a-changin"?. Surg Endosc. 2017; 32(4):2026-2037. DOI: 10.1007/s00464-017-5899-9. View

2.
Harter P, Sehouli J, Vergote I, Ferron G, Reuss A, Meier W . Randomized Trial of Cytoreductive Surgery for Relapsed Ovarian Cancer. N Engl J Med. 2021; 385(23):2123-2131. DOI: 10.1056/NEJMoa2103294. View

3.
Loverro M, Ergasti R, Conte C, Gallitelli V, Nachira D, Scaglione G . Minimally Invasive Secondary Cytoreductive Surgery for Superficial Celiac and Cardio-Phrenic Isolated Nodal Recurrence of Ovarian Cancer. Ann Surg Oncol. 2022; 29(4):2603-2604. DOI: 10.1245/s10434-021-11267-5. View

4.
Yin S, Gao W, Shi P, Xi M, Tang W, Zhang J . Primary Laparoscopic Surgery Does Not Affect the Prognosis of Early-Stage Ovarian Clear Cell Cancer. Cancer Manag Res. 2021; 13:6403-6409. PMC: 8372305. DOI: 10.2147/CMAR.S321173. View

5.
Gallotta V, Giudice M, Conte C, Sarandeses A, DIndinosante M, Federico A . Minimally invasive salvage lymphadenectomy in gynecological cancer patients: A single institution series. Eur J Surg Oncol. 2018; 44(10):1568-1572. DOI: 10.1016/j.ejso.2018.08.006. View