» Articles » PMID: 3872705

Increased Pulmonary Artery Diastolic-pulmonary Wedge Pressure Gradient After Cardiopulmonary Bypass

Overview
Specialty Anesthesiology
Date 1985 Mar 1
PMID 3872705
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

In 29 patients undergoing elective coronary artery bypass grafting, the diastolic pulmonary arterial pressure-pulmonary capillary wedge pressure gradient (DPAP-PCWP) and related haemodynamic parameters were determined before and after induction of anaesthesia, immediately after cardiopulmonary bypass (CPB) and one and three hours after CPB. The DPAP-PCWP gradient remained unchanged after induction of anaesthesia but was significantly increased after CPB. A gradient of 5 mmHg or greater was observed in 16 patients after CPB, whereas none of the patients showed such a gradient before CPB. A significant correlation was found between the change in DPAP-PCWP and the change in pulmonary vascular resistance (PVR). It is concluded that DPAP should not be used as a substitute of PCWP in the early postbypass period without frequent confirmation of the presence of the normal small DPAP-PCWP gradient. Since an increase of PVR may impair right ventricular ejection, we recommend the routine measurement of DPAP-PCWP gradient in the postbypass period.

Citing Articles

The diastolic pulmonary gradient does not predict survival in patients with pulmonary hypertension due to left heart disease.

Tampakakis E, Leary P, Selby V, De Marco T, Cappola T, Felker G JACC Heart Fail. 2014; 3(1):9-16.

PMID: 25453535 PMC: 4289416. DOI: 10.1016/j.jchf.2014.07.010.


Prognostic value of the pre-transplant diastolic pulmonary artery pressure-to-pulmonary capillary wedge pressure gradient in cardiac transplant recipients with pulmonary hypertension.

Tedford R, Beaty C, Mathai S, Kolb T, Damico R, Hassoun P J Heart Lung Transplant. 2014; 33(3):289-97.

PMID: 24462554 PMC: 3955214. DOI: 10.1016/j.healun.2013.11.008.

References
1.
Buchbinder N, Ganz W . Hemodynamic monitoring: invasive techniques. Anesthesiology. 1976; 45(2):146-55. DOI: 10.1097/00000542-197608000-00005. View

2.
Yelderman M, New Jr W, Rosenthal M, Ream A . Improved clinical measurement of pulmonary vascular resistance. Anesthesiology. 1980; 52(4):365-9. DOI: 10.1097/00000542-198004000-00019. View

3.
ENSON Y, Wood J, Mantaras N, Harvey R . The influence of heart rate on pulmonary arterial-left ventricular pressure relationships at end-diastole. Circulation. 1977; 56(4 Pt 1):533-9. DOI: 10.1161/01.cir.56.4.533. View

4.
Fitzpatrick G, HAMPSON L, Burgess J . Bedside determination of left atrial pressure. Can Med Assoc J. 1972; 106(12):1293-8. PMC: 1940444. View

5.
Lowenstein E, Johnston W, Lappas D, DAmbra M, SCHNEIDER R, Daggett W . Catastrophic pulmonary vasoconstriction associated with protamine reversal of heparin. Anesthesiology. 1983; 59(5):470-3. DOI: 10.1097/00000542-198311000-00022. View