Norepinephrine May Promote the Progression of Related Colorectal Cancer Via Quorum Sensing Signalling

Overview

Journal Virulence

Specialty Microbiology

Date 2024 May 9

PMID 38725098

Authors

Xinhao Du

Zhenzhen Tang

Li Yan

Ling Zhang

Qiao Zheng

Xianghao Zeng

Qing Hu

Qian Tian

Lanfan Liang

Xinyu Zhao

Jun Li

Ming Zhao

Xiangsheng Fu

Affiliations

Soon will be listed here.

Abstract

is closely correlated with tumorigenesis in colorectal cancer (CRC). We aimed to investigate the effects of host norepinephrine on the carcinogenicity of in CRC and reveal the underlying mechanism. The results revealed that both norepinephrine and bacterial quorum sensing (QS) molecule auto-inducer-2 (AI-2) were positively associated with the progression of related CRC ( < 0.01). studies, norepinephrine induced upregulation of QS-associated genes and promoted the virulence and proliferation of . Moreover, chronic stress significantly increased the colon tumour burden of Apc mice infected with ( < 0.01), which was decreased by a catecholamine inhibitor ( < 0.001). Our findings suggest that stress-induced norepinephrine may promote the progression of related CRC via bacterial QS signalling. These preliminary data provide a novel strategy for the management of pathogenic bacteria by targeting host hormones-bacterial QS inter-kingdom signalling.

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