Coagulopathy and Hemorrhage Associated with Cefoperazone Therapy in a Patient with Renal Failure

Overview

Journal South Med J

Specialties General Medicine
General Surgery

Date 1985 Apr 1

PMID 3872479

Citations 4

Authors

T D Shenkenberg

P A Mackowiak

J W Smith

Affiliations

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Abstract

We have reported life-threatening gastrointestinal hemorrhage with hypoprothrombinemia in a patient treated with cefoperazone for a urinary tract infection. The coagulation abnormality was rapidly corrected with administration of vitamin K and discontinuation of the antibiotic. This complication of cefoperazone therapy is not widely recognized and may be seen more frequently with increased use of the drug.

Citing Articles

Cefoperazone-induced Coagulopathy in Critically Ill Patients Admitted to Intensive Care Unit.

Gudivada K, Krishna B, Sampath S Indian J Crit Care Med. 2023; 27(3):183-189.

PMID: 36960109 PMC: 10028720. DOI: 10.5005/jp-journals-10071-24417.

Neglected vitamin K deficiency causing coagulation dysfunction in an older patient with pneumonia: a case report.

Wu Q, Wang L, Zhao R BMC Geriatr. 2022; 22(1):628.

PMID: 35907829 PMC: 9338575. DOI: 10.1186/s12877-022-03327-6.

Fatal Vitamin K-Dependent Coagulopathy Associated with Cefoperazone/Sulbactam: A Case Report.

Hu H Drug Saf Case Rep. 2019; 6(1):6.

PMID: 31201572 PMC: 6570729. DOI: 10.1007/s40800-019-0100-0.

Cefoperazone/Sulbactam-Induced Abdominal Wall Hematoma and Upper Gastrointestinal Bleeding: A Case Report and Review of the Literature.

Cai Z, Yang W, He Y, Chen Q, Wang S, Luo X Drug Saf Case Rep. 2016; 3(1):2.

PMID: 27747682 PMC: 5005745. DOI: 10.1007/s40800-016-0025-9.