Pace of Aging in Older Adults Matters for Healthspan and Lifespan

Overview

Journal medRxiv

Date 2024 May 7

PMID 38712264

Authors

A Balachandran

H Pei

Y Shi

J Beard

A Caspi

A Cohen

B W Domingue

C Eckstein Indik

L Ferrucci

A Furuya

M Kothari

T E Moffitt

C Ryan

V Skirbekk

Y Zhang

D W Belsky

Affiliations

Soon will be listed here.

Abstract

As societies age, policy makers need tools to understand how demographic aging will affect population health and to develop programs to increase healthspan. The current metrics used for policy analysis do not distinguish differences caused by early-life factors, such as prenatal care and nutrition, from those caused by ongoing changes in people's bodies due to aging. Here we introduce an adapted Pace of Aging method designed to quantify differences between individuals and populations in the speed of aging-related health declines. The adapted Pace of Aging method, implemented in data from the US Health and Retirement Study and English Longitudinal Study of Aging (N=21,463), integrates longitudinal data on blood biomarkers, physical measurements, and functional tests. It reveals stark differences in rates of aging between population subgroups and demonstrates strong and consistent prospective associations with incident morbidity, disability, and mortality. Pace of Aging can advance the population science of healthy longevity.

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