Research Progress on the Inhibition of Oxidative Stress by Teriparatide in Spinal Cord Injury

Overview

Journal Front Neurol

Specialty Neurology

Date 2024 May 7

PMID 38711562

Authors

Gangtong Ai

Moliang Xiong

Liang Deng

Jihuan Zeng

Qiang Xiao

Affiliations

Soon will be listed here.

Abstract

Spinal cord injury (SCI) is currently a highly disabling disease, which poses serious harm to patients and their families. Due to the fact that primary SCI is caused by direct external force, current research on SCI mainly focuses on the treatment and prevention of secondary SCI. Oxidative stress is one of the important pathogenic mechanisms of SCI, and intervention of oxidative stress may be a potential treatment option for SCI. Teriparatide is a drug that regulates bone metabolism, and recent studies have found that it has the ability to counteract oxidative stress and is closely related to SCI. This article summarizes the main pathological mechanisms of oxidative stress in SCI, as well as the relationship between them with teriparatide, and explores the therapeutic potential of teriparatide in SCI.

Citing Articles

Effects of Teriparatide and Alendronate on Functional Recovery from Spinal Cord Injury and Postinjury Bone Loss.

Wang S, Zhu J, Feng Y, Hua Y, You G, Su J Biomedicines. 2025; 13(2).

PMID: 40002755 PMC: 11852434. DOI: 10.3390/biomedicines13020342.

Nrf2 Signaling Pathway: Focus on Oxidative Stress in Spinal Cord Injury.

Xiao C, Lai H, Zhou J, Liu W, Zhao M, Zhao K Mol Neurobiol. 2024; 62(2):2230-2249.

PMID: 39093381 DOI: 10.1007/s12035-024-04394-z.

References

Martin T, Sims N, Seeman E . Physiological and Pharmacological Roles of PTH and PTHrP in Bone Using Their Shared Receptor, PTH1R. Endocr Rev. 2021; 42(4):383-406. DOI: 10.1210/endrev/bnab005. View

Gao W, Guo L, Yang Y, Wang Y, Xia S, Gong H . Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity. Front Cell Dev Biol. 2022; 9:809952. PMC: 8847224. DOI: 10.3389/fcell.2021.809952. View

Sivandzade F, Prasad S, Bhalerao A, Cucullo L . NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches. Redox Biol. 2018; 21:101059. PMC: 6302038. DOI: 10.1016/j.redox.2018.11.017. View

Slater P, Dominguez-Romero M, Villarreal M, Eisner V, Larrain J . Mitochondrial function in spinal cord injury and regeneration. Cell Mol Life Sci. 2022; 79(5):239. PMC: 11072423. DOI: 10.1007/s00018-022-04261-x. View

Sies H . Oxidative eustress: On constant alert for redox homeostasis. Redox Biol. 2021; 41:101867. PMC: 7930632. DOI: 10.1016/j.redox.2021.101867. View

Casper E . The crosstalk between Nrf2 and NF-κB pathways in coronary artery disease: Can it be regulated by SIRT6?. Life Sci. 2023; 330:122007. DOI: 10.1016/j.lfs.2023.122007. View

Li Z, Wu F, Xu D, Zhi Z, Xu G . Inhibition of TREM1 reduces inflammation and oxidative stress after spinal cord injury (SCI) associated with HO-1 expressions. Biomed Pharmacother. 2018; 109:2014-2021. DOI: 10.1016/j.biopha.2018.08.159. View

Li Z, Zhao T, Ding J, Gu H, Wang Q, Wang Y . A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury. Bioact Mater. 2022; 19:550-568. PMC: 9108756. DOI: 10.1016/j.bioactmat.2022.04.029. View

Wang T, Han C, Tian P, Li P, Ma X . Role of Teriparatide in Glucocorticoid-induced Osteoporosis through Regulating Cellular Reactive Oxygen Species. Orthop Surg. 2018; 10(2):152-159. PMC: 6594530. DOI: 10.1111/os.12369. View

10.

Rouleau P, Ung R, Lapointe N, Guertin P . Hormonal and immunological changes in mice after spinal cord injury. J Neurotrauma. 2007; 24(2):367-78. DOI: 10.1089/neu.2006.0117. View

11.

Yang Y, Lei H, Wang B . Effect of the PTHrP(1-34) analog abaloparatide on inducing chondrogenesis involves inhibition of intracellular reactive oxygen species production. Biochem Biophys Res Commun. 2019; 509(4):960-965. PMC: 7768806. DOI: 10.1016/j.bbrc.2019.01.049. View

12.

Mechanick J, Pomerantz F, Flanagan S, Stein A, Gordon W, Ragnarsson K . Parathyroid hormone suppression in spinal cord injury patients is associated with the degree of neurologic impairment and not the level of injury. Arch Phys Med Rehabil. 1997; 78(7):692-6. DOI: 10.1016/s0003-9993(97)90075-7. View

13.

Ji Z, Gao G, Ma Y, Luo J, Zhang G, Yang H . Highly bioactive iridium metal-complex alleviates spinal cord injury via ROS scavenging and inflammation reduction. Biomaterials. 2022; 284:121481. DOI: 10.1016/j.biomaterials.2022.121481. View

14.

Xia M, Zhang Y, Wu H, Zhang Q, Liu Q, Li G . Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury. Int Immunopharmacol. 2022; 111:109120. DOI: 10.1016/j.intimp.2022.109120. View

15.

Gambardella J, De Rosa M, Sorriento D, Prevete N, Fiordelisi A, Ciccarelli M . Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications. Oxid Med Cell Longev. 2019; 2018:9582319. PMC: 6313989. DOI: 10.1155/2018/9582319. View

16.

Forman H, Zhang H . Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov. 2021; 20(9):689-709. PMC: 8243062. DOI: 10.1038/s41573-021-00233-1. View

17.

Hill R, Singh I, Wang J, Kulbe J, Hall E . Protective effects of phenelzine administration on synaptic and non-synaptic cortical mitochondrial function and lipid peroxidation-mediated oxidative damage following TBI in young adult male rats. Exp Neurol. 2020; 330:113322. PMC: 7418938. DOI: 10.1016/j.expneurol.2020.113322. View

18.

Foo J, Bellot G, Pervaiz S, Alonso S . Mitochondria-mediated oxidative stress during viral infection. Trends Microbiol. 2022; 30(7):679-692. DOI: 10.1016/j.tim.2021.12.011. View

19.

Xu X, Wang X, Yang Y, Ares I, Martinez M, Lopez-Torres B . Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage. Arch Toxicol. 2022; 96(6):1493-1520. DOI: 10.1007/s00204-022-03267-5. View

20.

Zrzavy T, Schwaiger C, Wimmer I, Berger T, Bauer J, Butovsky O . Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury. Brain. 2021; 144(1):144-161. PMC: 7880675. DOI: 10.1093/brain/awaa360. View