Efficacy and Safety of Acupuncture Treatment for Post-stroke Depression: A Protocol for Systematic Review and Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 May 6

PMID 38709750

Authors

Demin Kong

Yangyang Li

Wei Zou

Affiliations

Soon will be listed here.

Abstract

Background: Post-stroke depression is a common complication of stroke, with a high incidence rate and low recognition rate. Many patients do not receive effective intervention at the onset, which affects subsequent treatment outcomes. Post-stroke depression not only impacts the patient's mental well-being but also increases the risk of stroke recurrence and poor prognosis. Therefore, it has become a significant public health concern. Acupuncture has gained significant popularity in the treatment of post-stroke depression. However, there are inconsistent clinical research results regarding its efficacy and safety. This systematic review aims to gather and critically assess all available evidence regarding the effectiveness and safety of acupuncture in the treatment of post-stroke depression in patients.

Methods: We will conduct thorough searches for relevant studies in multiple electronic databases (PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP Database, Wan-fang Data and China Biomedical Database). Our search scope will encompass studies published from the inception of each database until September 2023. To evaluate the potential bias in all the included studies, we will adhere to the guidelines offered in the Cochrane Handbook. The total effective rate will be the primary outcome. To conduct a systematic review, we will employ RevMan 5.4 software.

Results: This study will obtain efficacy and safety of acupuncture for the treatment of post-stroke depression.

Conclusions: The conclusions of this study will provide evidence-based perspectives that can guide clinical decision-making regarding the practicality and recommended timing of using acupuncture to treat post-stroke depression. Furthermore, this study will help advance the clinical application of acupuncture treatment for post-stroke depression and enhance its efficacy while ensuring patient safety.

Citing Articles

Modulating Gut Microbiota: The Mechanism of Electroacupuncture at the "Siguan" Acupoints in Alleviating Post-Stroke Depression.

Li Z, Li L, Xu H, Kang Z, Shi X, Zhang P Neuropsychiatr Dis Treat. 2025; 21:281-294.

PMID: 39967830 PMC: 11834731. DOI: 10.2147/NDT.S495460.

The potential impact of COVID-19 vaccination on patients with immune thrombocytopenic purpura: A protocol for systematic review and meta-analysis.

Li Y, Kong D, Ding Y, Wang J PLoS One. 2024; 19(11):e0308546.

PMID: 39527538 PMC: 11554223. DOI: 10.1371/journal.pone.0308546.

References

Li P, Peng X, Niu X, Xu L, Ng E, Wang C . Efficacy of acupuncture for endometriosis-associated pain: a multicenter randomized single-blind placebo-controlled trial. Fertil Steril. 2023; 119(5):815-823. DOI: 10.1016/j.fertnstert.2023.01.034. View

Zhang S, Wang Y, Zhang C, Zhang C, Xiao P, Li Q . Effect of Interactive Dynamic Scalp Acupuncture on Post-Stroke Cognitive Function, Depression, and Anxiety: A Multicenter, Randomized, Controlled Trial. Chin J Integr Med. 2021; 28(2):106-115. DOI: 10.1007/s11655-021-3338-1. View

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M . Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015; 350:g7647. DOI: 10.1136/bmj.g7647. View

Fan M, Dai G, Li R, Wu X . Efficacy of Acupuncture in the Treatment of Essential Hypertension: An Overview of Systematic Reviews and Meta-Analyses. Cardiovasc Ther. 2023; 2023:2722727. PMC: 10129421. DOI: 10.1155/2023/2722727. View

Hackett M, Kohler S, OBrien J, Mead G . Neuropsychiatric outcomes of stroke. Lancet Neurol. 2014; 13(5):525-34. DOI: 10.1016/S1474-4422(14)70016-X. View

Lam Ching W, Li H, Guo J, Yao L, Chau J, Lo S . Acupuncture for post-stroke depression: a systematic review and network meta-analysis. BMC Psychiatry. 2023; 23(1):314. PMC: 10161596. DOI: 10.1186/s12888-023-04749-1. View

Chen H, Liu F, Sun D, Zhang J, Luo S, Liao Q . The potential risk factors of early-onset post-stroke depression from immuno-inflammatory perspective. Front Immunol. 2022; 13:1000631. PMC: 9549963. DOI: 10.3389/fimmu.2022.1000631. View

Guo W, Cui H, Zhang L, Du R, Yuan H, Zheng S . Acupuncture for the Treatment of Migraine: An Overview of Systematic Reviews. Curr Pain Headache Rep. 2023; 27(8):239-257. DOI: 10.1007/s11916-023-01120-7. View

Frank D, Gruenbaum B, Zlotnik A, Semyonov M, Frenkel A, Boyko M . Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review. Int J Mol Sci. 2022; 23(23). PMC: 9738261. DOI: 10.3390/ijms232315114. View

10.

Feng J, He H, Wang Y, Zhang X, Zhang X, Zhang T . The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review. Front Endocrinol (Lausanne). 2022; 13:1009537. PMC: 9624472. DOI: 10.3389/fendo.2022.1009537. View

11.

Balshem H, Helfand M, Schunemann H, Oxman A, Kunz R, Brozek J . GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011; 64(4):401-6. DOI: 10.1016/j.jclinepi.2010.07.015. View

12.

Wu D, Zhang G, Zhao C, Yang Y, Miao Z, Xu X . Interleukin-18 from neurons and microglia mediates depressive behaviors in mice with post-stroke depression. Brain Behav Immun. 2020; 88:411-420. DOI: 10.1016/j.bbi.2020.04.004. View

13.

Cai W, Mueller C, Li Y, Shen W, Stewart R . Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis. Ageing Res Rev. 2019; 50:102-109. DOI: 10.1016/j.arr.2019.01.013. View

14.

Jiang H, Deng S, Zhang J, Chen J, Li B, Zhu W . Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role. Front Neurosci. 2023; 17:1146946. PMC: 10070763. DOI: 10.3389/fnins.2023.1146946. View

15.

Hang X, Li J, Zhang Y, Li Z, Zhang Y, Ye X . Efficacy of frequently-used acupuncture methods for specific parts and conventional pharmaceutical interventions in treating post-stroke depression patients: A network meta-analysis. Complement Ther Clin Pract. 2021; 45:101471. DOI: 10.1016/j.ctcp.2021.101471. View

16.

Oni O, Olagunju A, Olisah V, Aina O, Ojini F . Post-stroke depression: Prevalence, associated factors and impact on quality of life among outpatients in a Nigerian hospital. S Afr J Psychiatr. 2018; 24:1058. PMC: 6138133. DOI: 10.4102/sajpsychiatry.v24i0.1058. View

17.

Esparrago Llorca G, Castilla-Guerra L, Fernandez Moreno M, Ruiz Doblado S, Jimenez Hernandez M . Post-stroke depression: an update. Neurologia. 2012; 30(1):23-31. DOI: 10.1016/j.nrl.2012.06.008. View

18.

Ang L, Kim H, Heo J, Choi T, Lee H, Kim J . Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis. Complement Ther Clin Pract. 2023; 52:101763. DOI: 10.1016/j.ctcp.2023.101763. View

19.

Ayerbe L, Ayis S, Wolfe C, Rudd A . Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis. Br J Psychiatry. 2013; 202(1):14-21. DOI: 10.1192/bjp.bp.111.107664. View

20.

Liu R, Zhang K, Tong Q, Cui G, Ma W, Shen W . Acupuncture for post-stroke depression: a systematic review and meta-analysis. BMC Complement Med Ther. 2021; 21(1):109. PMC: 8017746. DOI: 10.1186/s12906-021-03277-3. View