Epidemiology and Risk Factors for Staphylococcal Urinary Tract Infections in the Moroccan Casablanca Area

Overview

Journal World J Urol

Specialty Urology

Date 2024 May 6

PMID 38709302

Authors

Rafik Aniba

Asmaa Dihmane

Habiba Raqraq

Amina Ressmi

Kaotar Nayme

Mohammed Timinouni

Abouddihaj Barguigua

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aimed to ascertain the prevalence and risk factors for developing staphylococcal urinary tract infections (UTIs) in the Casablanca area of Morocco.

Methods: In Casablanca, Morocco, a retrospective evaluation of 772 UTIs patients was conducted between January 2020 and December 2022. The research included two groups of patients: those with staphylococcal UTIs and those without. Sex, age, chronic illnesses, antibiotic exposure, urinary catheterization, urological surgery, and UTIs history were the risk variables assessed. We employed a logistic regression model to identify the characteristics that were predictive of staphylococcal UTIs.

Results: Eight staphylococcal species were responsible for 16.84% of UTIs in 772 non-repeating individuals. Patients infected with S. saprophyticus (35.38%) were the most common, followed by those infected with S. epidermidis (24.61%), S. aureus (13.85%), and S. hemolyticus (10.78%). Multivariate logistic regression analysis revealed that male sex (95% CI: 0.261-0.563), immunosuppression and immunosuppressive treatments (95% CI: 0.0068-0.64), chronic diseases (95% CI: 0.407-0.965), previous UTIs (95% CI: 0.031-0.228), frequency of urination more than 8 times a day (95% CI:1.04-3.29), frequency of urination once or twice a day (95% CI: 1.05-2.39), and urinary catheterization (95% CI: 0.02-0.22) were the most likely predictors of staphylococcal UTIs. In addition, a larger proportion of patients with staphylococcal UTIs were made aware of the risk factors associated with staphylococcal UTIs (52.31%, χ2 = 4.82, = 0.014).

Conclusions: This is the first global study to evaluate the predictive factors for acquiring UTIs caused by staphylococci. Monitoring these factors will enable medical authorities to devise effective strategies for managing UTIs and combating antibiotic resistance.

References

Gajdacs M, Abrok M, Lazar A, Burian K . Increasing relevance of Gram-positive cocci in urinary tract infections: a 10-year analysis of their prevalence and resistance trends. Sci Rep. 2020; 10(1):17658. PMC: 7573585. DOI: 10.1038/s41598-020-74834-y. View

Alfaifi J, Alqahtani Y, Alqahtani M, Alqarni A, Alshahrani A, Alshomrani R . Knowledge and Attitudes of Parents Regarding Neonatal Jaundice in Bisha City, Saudi Arabia. Cureus. 2023; 15(9):e44916. PMC: 10560542. DOI: 10.7759/cureus.44916. View

Natsis N, Cohen P . Coagulase-Negative Staphylococcus Skin and Soft Tissue Infections. Am J Clin Dermatol. 2018; 19(5):671-677. DOI: 10.1007/s40257-018-0362-9. View

Issakhanian L, Behzadi P . Antimicrobial Agents and Urinary Tract Infections. Curr Pharm Des. 2019; 25(12):1409-1423. DOI: 10.2174/1381612825999190619130216. View

Arias C, Murray B . The rise of the Enterococcus: beyond vancomycin resistance. Nat Rev Microbiol. 2012; 10(4):266-78. PMC: 3621121. DOI: 10.1038/nrmicro2761. View

Sader H, Farrell D, Flamm R, Jones R . Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalised with pneumonia in US and European hospitals: results from the SENTRY Antimicrobial Surveillance Program, 2009-2012. Int J Antimicrob Agents. 2014; 43(4):328-34. DOI: 10.1016/j.ijantimicag.2014.01.007. View

Selim S, Faried O, Almuhayawi M, Saleh F, Sharaf M, El Nahhas N . Incidence of Vancomycin-Resistant Strains among Patients with Urinary Tract Infections. Antibiotics (Basel). 2022; 11(3). PMC: 8944512. DOI: 10.3390/antibiotics11030408. View

Bizuayehu H, Bitew A, Abdeta A, Ebrahim S . Catheter-associated urinary tract infections in adult intensive care units at a selected tertiary hospital, Addis Ababa, Ethiopia. PLoS One. 2022; 17(3):e0265102. PMC: 8939826. DOI: 10.1371/journal.pone.0265102. View

Storme O, Saucedo J, Garcia-Mora A, Dehesa-Davila M, Naber K . Risk factors and predisposing conditions for urinary tract infection. Ther Adv Urol. 2019; 11:1756287218814382. PMC: 6502981. DOI: 10.1177/1756287218814382. View

10.

Salari N, Karami M, Bokaee S, Chaleshgar M, Shohaimi S, Akbari H . The prevalence of urinary tract infections in type 2 diabetic patients: a systematic review and meta-analysis. Eur J Med Res. 2022; 27(1):20. PMC: 8817604. DOI: 10.1186/s40001-022-00644-9. View

11.

Dimitrijevic Z, Paunovic G, Tasic D, Mitic B, Basic D . Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections. Sci Rep. 2021; 11(1):14414. PMC: 8277778. DOI: 10.1038/s41598-021-93912-3. View

12.

Anggi A, Wijaya D, Ramayani O . Risk Factors for Catheter-Associated Urinary Tract Infection and Uropathogen Bacterial Profile in the Intensive Care Unit in Hospitals in Medan, Indonesia. Open Access Maced J Med Sci. 2020; 7(20):3488-3492. PMC: 6980809. DOI: 10.3889/oamjms.2019.684. View

13.

Patel P, Advani S, Kofman A, Lo E, Maragakis L, Pegues D . Strategies to prevent catheter-associated urinary tract infections in acute-care hospitals: 2022 Update. Infect Control Hosp Epidemiol. 2023; 44(8):1209-1231. PMC: 11287483. DOI: 10.1017/ice.2023.137. View

14.

Chao C, Lee S, Wang J, Chien K, Huang J . Frailty increases the risk for developing urinary tract infection among 79,887 patients with diabetic mellitus and chronic kidney disease. BMC Geriatr. 2021; 21(1):349. PMC: 8186134. DOI: 10.1186/s12877-021-02299-3. View

15.

Ripa F, Pietropaolo A, Montanari E, Hameed B, Gauhar V, Somani B . Association of Kidney Stones and Recurrent UTIs: the Chicken and Egg Situation. A Systematic Review of Literature. Curr Urol Rep. 2022; 23(9):165-174. PMC: 9492590. DOI: 10.1007/s11934-022-01103-y. View

16.

Brain E, Geraghty R, Cook P, Roderick P, Somani B . Risk of UTI in kidney stone formers: a matched-cohort study over a median follow-up of 19 years. World J Urol. 2021; 39(8):3095-3101. PMC: 8405492. DOI: 10.1007/s00345-020-03564-7. View

17.

Yongzhi L, Shi Y, Jia L, Yili L, Xingwang Z, Xue G . Risk factors for urinary tract infection in patients with urolithiasis-primary report of a single center cohort. BMC Urol. 2018; 18(1):45. PMC: 5963162. DOI: 10.1186/s12894-018-0359-y. View