Advancing Tissue Damage Repair in Geriatric Diseases: Prospects of Combining Stem Cell-Derived Exosomes with Hydrogels

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2024 May 6

PMID 38708181

Authors

Ling Shi

Yunjun Zhou

Yongkui Yin

Jin Zhang

Kaiyuan Chen

Sen Liu

Peijian Chen

Hua Jiang

Jieting Liu

Yan Wu

Affiliations

Soon will be listed here.

Abstract

Geriatric diseases are a group of diseases with unique characteristics related to senility. With the rising trend of global aging, senile diseases now mainly include endocrine, cardiovascular, neurodegenerative, skeletal, and muscular diseases and cancer. Compared with younger populations, the structure and function of various cells, tissues and organs in the body of the elderly undergo a decline as they age, rendering them more susceptible to external factors and diseases, leading to serious tissue damage. Tissue damage presents a significant obstacle to the overall health and well-being of older adults, exerting a profound impact on their quality of life. Moreover, this phenomenon places an immense burden on families, society, and the healthcare system.In recent years, stem cell-derived exosomes have become a hot topic in tissue repair research. The combination of these exosomes with biomaterials allows for the preservation of their biological activity, leading to a significant improvement in their therapeutic efficacy. Among the numerous biomaterial options available, hydrogels stand out as promising candidates for loading exosomes, owing to their exceptional properties. Due to the lack of a comprehensive review on the subject matter, this review comprehensively summarizes the application and progress of combining stem cell-derived exosomes and hydrogels in promoting tissue damage repair in geriatric diseases. In addition, the challenges encountered in the field and potential prospects are presented for future advancements.

References

Yuan M, Liu K, Jiang T, Li S, Chen J, Wu Z . GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing. J Nanobiotechnology. 2022; 20(1):147. PMC: 8934449. DOI: 10.1186/s12951-022-01354-4. View

Palanisamy V, Sharma S, Deshpande A, Zhou H, Gimzewski J, Wong D . Nanostructural and transcriptomic analyses of human saliva derived exosomes. PLoS One. 2010; 5(1):e8577. PMC: 2797607. DOI: 10.1371/journal.pone.0008577. View

Li J, Wei L, Han Z, Chen Z . Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p. Eur J Pharmacol. 2019; 852:68-76. DOI: 10.1016/j.ejphar.2019.01.022. View

Qi H, Liu D, Xiao D, Tian D, Su Y, Jin S . Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways. In Vitro Cell Dev Biol Anim. 2019; 55(3):203-210. DOI: 10.1007/s11626-019-00330-x. View

Naji A, Eitoku M, Favier B, Deschaseaux F, Rouas-Freiss N, Suganuma N . Biological functions of mesenchymal stem cells and clinical implications. Cell Mol Life Sci. 2019; 76(17):3323-3348. PMC: 11105258. DOI: 10.1007/s00018-019-03125-1. View

Song Y, You Y, Xu X, Lu J, Huang X, Zhang J . Adipose-Derived Mesenchymal Stem Cell-Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin Regeneration. Adv Sci (Weinh). 2023; 10(30):e2304023. PMC: 10602544. DOI: 10.1002/advs.202304023. View

Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R . Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Arthritis Rheumatol. 2015; 67(8):2141-53. PMC: 4519411. DOI: 10.1002/art.39182. View

Wang C, Wang M, Xu T, Zhang X, Lin C, Gao W . Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration. Theranostics. 2019; 9(1):65-76. PMC: 6332800. DOI: 10.7150/thno.29766. View

Wang R, Xu B . TGF-β1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6. Cell Tissue Res. 2021; 384(1):113-127. DOI: 10.1007/s00441-020-03319-1. View

10.

Zhang Z, Wang C, Li T, Liu Z, Li L . Comparison of ultracentrifugation and density gradient separation methods for isolating Tca8113 human tongue cancer cell line-derived exosomes. Oncol Lett. 2014; 8(4):1701-1706. PMC: 4156197. DOI: 10.3892/ol.2014.2373. View

11.

Talman V, Ruskoaho H . Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration. Cell Tissue Res. 2016; 365(3):563-81. PMC: 5010608. DOI: 10.1007/s00441-016-2431-9. View

12.

Nagaishi K, Mizue Y, Chikenji T, Otani M, Nakano M, Konari N . Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes. Sci Rep. 2016; 6:34842. PMC: 5056395. DOI: 10.1038/srep34842. View

13.

Thery C, Zitvogel L, Amigorena S . Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002; 2(8):569-79. DOI: 10.1038/nri855. View

14.

Dai C, Shih S, Khachemoune A . Skin substitutes for acute and chronic wound healing: an updated review. J Dermatolog Treat. 2018; 31(6):639-648. DOI: 10.1080/09546634.2018.1530443. View

15.

Wang L, Wang J, Zhou X, Sun J, Zhu B, Duan C . A New Self-Healing Hydrogel Containing hucMSC-Derived Exosomes Promotes Bone Regeneration. Front Bioeng Biotechnol. 2020; 8:564731. PMC: 7521201. DOI: 10.3389/fbioe.2020.564731. View

16.

Abramoff B, Caldera F . Osteoarthritis: Pathology, Diagnosis, and Treatment Options. Med Clin North Am. 2020; 104(2):293-311. DOI: 10.1016/j.mcna.2019.10.007. View

17.

Ju Y, Hu Y, Yang P, Xie X, Fang B . Extracellular vesicle-loaded hydrogels for tissue repair and regeneration. Mater Today Bio. 2023; 18:100522. PMC: 9803958. DOI: 10.1016/j.mtbio.2022.100522. View

18.

Tao S, Guo S, Li M, Ke Q, Guo Y, Zhang C . Chitosan Wound Dressings Incorporating Exosomes Derived from MicroRNA-126-Overexpressing Synovium Mesenchymal Stem Cells Provide Sustained Release of Exosomes and Heal Full-Thickness Skin Defects in a Diabetic Rat Model. Stem Cells Transl Med. 2017; 6(3):736-747. PMC: 5442792. DOI: 10.5966/sctm.2016-0275. View

19.

Shen K, Duan A, Cheng J, Yuan T, Zhou J, Song H . Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway. Acta Biomater. 2022; 143:173-188. DOI: 10.1016/j.actbio.2022.02.026. View

20.

Mehta P, Sharma M, Devi M . Hydrogels: An overview of its classifications, properties, and applications. J Mech Behav Biomed Mater. 2023; 147:106145. DOI: 10.1016/j.jmbbm.2023.106145. View