» Articles » PMID: 38708172

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Specialty Hematology
Date 2024 May 6
PMID 38708172
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Abstract

A cluster randomized control trial study was conducted in Ballabgarh block of Faridabad District, Haryana, India. Baseline data of a total of 198 non-anemic and 202 anemic adolescent girls (12-19 years) was analyzed for hemoglobin and serum level of hepcidin, ferritin, folate acid, soluble transferrin receptor, vitamin B and CRP. Deficiency of iron ( < 0.001), folate ( < 0.01) and their mixed deficiency ( < 0.001) significantly increased with increasing severity of anaemia and contributed to 48.7% mild anaemia and 66.9% moderate anaemia. Anaemia of inflammation contributed to 16.2% of mild anaemia and 11.7% of moderate anaemia. More than one third of mild anaemia is caused by other causes. Current iron and folic acid program can alleviate around more than 2/3rd moderate anaemia and around half of mild anaemia among adolescent girls. Unknown causes of anaemia need further investigation.

References
1.
Uotila M, Ruoslahti E, Engvall E . Two-site sandwich enzyme immunoassay with monoclonal antibodies to human alpha-fetoprotein. J Immunol Methods. 1981; 42(1):11-5. DOI: 10.1016/0022-1759(81)90219-2. View

2.
Petry N, Olofin I, Hurrell R, Boy E, Wirth J, Moursi M . The Proportion of Anemia Associated with Iron Deficiency in Low, Medium, and High Human Development Index Countries: A Systematic Analysis of National Surveys. Nutrients. 2016; 8(11). PMC: 5133080. DOI: 10.3390/nu8110693. View

3.
Garcia-Casal M, Pena-Rosas J, Urrechaga E, Escanero J, Huo J, Martinez R . Performance and comparability of laboratory methods for measuring ferritin concentrations in human serum or plasma: A systematic review and meta-analysis. PLoS One. 2018; 13(5):e0196576. PMC: 5933730. DOI: 10.1371/journal.pone.0196576. View

4.
Beard J . Iron requirements in adolescent females. J Nutr. 2000; 130(2S Suppl):440S-442S. DOI: 10.1093/jn/130.2.440S. View

5.
de Benoist B . Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food Nutr Bull. 2008; 29(2 Suppl):S238-44. DOI: 10.1177/15648265080292S129. View