Ameliorative Effect of Total Ginsenosides from Heat-treated Fresh Ginseng Against Cyclophosphamide-induced Liver Injury in Mice

Overview

Journal Curr Res Food Sci

Date 2024 May 6

PMID 38708102

Authors

Ping Tang

Guangquan Ren

Hongyang Zou

Sitong Liu

Junshun Zhang

Zhiyi Ai

Yue Hu

Linlin Cui

Bo Nan

Zhicheng Zhang

Yuhua Wang

Affiliations

Soon will be listed here.

Abstract

This study evaluated the effect of heat treatment on the conversion of ginsenoside and the ameliorative effect of heat-treated total ginsenoside (HG) from fresh ginseng on cyclophosphamide (CTX)-induced liver injury. LC-MS analysis revealed that the content of rare ginsenosides increased markedly after heat treatment. HG significantly attenuated CTX-induced hepatic histopathological injury in mice. Western blotting analysis showed that untreated total ginsenoside (UG) and HG regulated the Nrf2/HO-1 and TLR4/MAPK pathways. Importantly, these results may be relevant to the modulation of the intestinal flora. UG and HG significantly increased the short-chain fatty acids (SCFAs)-producing bacteria and reduced the LPS-producing bacteria and . These changes in intestinal flora affected the levels of TNF-α, LPS and SCFAs. In short, UG and HG alleviated CTX-induced liver injury by regulating the intestinal flora and the LPS-TLR4-MAPK pathway, and HG was more effective. HG has the potential to be a functional food that can alleviate chemical liver injury.

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