Correlation of Leptin in Patients With Type 2 Diabetes Mellitus

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 May 6

PMID 38707092

Authors

Kajol Manglani

Nabila Nowshin Anika

Dhriti Patel

Sharan Jhaveri

Chaithanya Avanthika

Sourav Sudan

Zainab Alimohamed

Kripa Tiwari

Affiliations

Soon will be listed here.

Abstract

The exponential increase in diabetes mellitus (DM) poses serious public health concerns. In this review, we focus on the role of leptin in type 2 DM. The peripheral actions of leptin consist of upregulating proinflammatory cytokines which play an important role in the pathogenesis of type 2 DM and insulin resistance. Moreover, leptin is known to inhibit insulin secretion and plays a significant role in insulin resistance in obesity and type 2 DM. A literature search was conducted on Medline, Cochrane, Embase, and Google Scholar for relevant articles published until December 2023. The following search strings and Medical Subject Headings (MeSH terms) were used: "Diabetes Mellitus," "Leptin," "NPY," and "Biomarker." This article aims to discuss the physiology of leptin in type 2 DM, its glucoregulatory actions, its relationship with appetite, the impact that various lifestyle modifications can have on leptin levels, and, finally, explore leptin as a potential target for various treatment strategies.

Citing Articles

Altered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes.

Evans A, Tu H, Li Y, Shabaltiy B, Whitney L, Carpenter K Front Physiol. 2025; 16:1547901.

PMID: 40078371 PMC: 11897569. DOI: 10.3389/fphys.2025.1547901.

Adipsin and Leptin Levels in Type 2 Diabetic Patients on Sitagliptin and Metformin Versus Metformin Therapy.

Mohammed S, Fathi Z, Mohammad J Sisli Etfal Hastan Tıp Bul. 2025; 58(4):491-500.

PMID: 39816418 PMC: 11729846. DOI: 10.14744/SEMB.2024.74483.

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