Inhibition of Nogo-B Reduces the Progression of Pancreatic Cancer by Regulation NF-κB/GLUT1 and SREBP1 Pathways

Overview

Journal iScience

Publisher Cell Press

Date 2024 May 6

PMID 38706871

Authors

Tianxiang Wang

Min Zhang

Xinyu Gong

Wanjing Chen

Ying Peng

Chenzhong Liao

Hongmei Xu

Qingshan Li

Guodong Shen

Huirong Ren

Yaxin Zhu

Baotong Zhang

Jiali Mao

Lingling Wei

Yuanli Chen

Xiaoxiao Yang

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer (PC) is a lethal disease and associated with metabolism dysregulation. Nogo-B is related to multiple metabolic related diseases and types of cancers. However, the role of Nogo-B in PC remains unknown. , we showed that cell viability and migration was largely reduced in Nogo-B knockout or knockdown cells, while enhanced by Nogo-B overexpression. Consistently, orthotopic tumor and metastasis was reduced in global Nogo knockout mice. Furthermore, we indicated that glucose enhanced cell proliferation was associated to the elevation expression of Nogo-B and nuclear factor κB (NF-κB). While, NF-κB, glucose transporter type 1 (GLUT1) and sterol regulatory element-binding protein 1 (SREBP1) expression was reduced in Nogo-B deficiency cells. In addition, we showed that GLUT1 and SREBP1 was downstream target of NF-κB. Therefore, we demonstrated that Nogo deficiency inhibited PC progression is regulated by the NF-κB/GLUT1 and SREBP1 pathways, and suggested that Nogo-B may be a target for PC therapy.

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