Receptor-interacting Protein Kinase-3 (RIPK3): a New Biomarker for Necrotising Enterocolitis in Preterm Infants

Overview

Journal Pediatr Surg Int

Specialties General Surgery
Pediatrics

Date 2024 May 2

PMID 38696138

Authors

Lirong Shen

Zuming Yang

Chuchu Gao

Lili Li

Yu Wang

Yan Cai

Zongtai Feng

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to evaluate the role of receptor-interacting protein kinase-3 (RIPK3) in the diagnosis, estimation of disease severity, and prognosis of premature infants with necrotising enterocolitis (NEC).

Methods: RIPK3, lactic acid (LA), and C-reactive protein (CRP) levels were measured in the peripheral blood of 108 premature infants between 2019 and 2023, including 24 with stage II NEC, 18 with stage III NEC and 66 controls. Diagnostic values of the indicators for NEC were evaluated via receiver operating characteristic (ROC) curve analysis.

Results: Plasma RIPK3 and LA levels upon NEC suspicion in neonates with stage III NEC were 32.37 ± 16.20 ng/mL. The ROC curve for the combination of RIPK3, LA, CRP for NEC diagnosis were 0.925. The time to full enteral feeding (FEFt) after recovery from NEC was different between two expression groups of plasma RIPK3 (RIPK3 < 20.06 ng/mL and RIPK3 ≥ 20.06 ng/mL).

Conclusion: Plasma RIPK3 can be used as a promising marker for the diagnosis and estimation of disease severity of premature infants with NEC and for the guidance on proper feeding strategies after recovery from NEC.

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