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The CANMAT and ISBD Guidelines for the Treatment of Bipolar Disorder: Summary and a 2023 Update of Evidence

Overview
Specialty Medical Education
Date 2024 May 2
PMID 38695002
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Abstract

Bipolar disorder is a complex and heterogeneous psychiatric condition that affects more than 2% of the population. The assessment and treatment of bipolar disorder can be a challenge for clinicians, given its clinical complexity and the rapidly changing treatment landscape with the growing range of treatment options that are becoming available for various phases of the illness. To help clinicians navigate the complexity involved in the assessment and management of bipolar disorder, the guidelines of the 2018 Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) synthesized the evidence on the efficacy, safety, and tolerability of treatments for bipolar disorder and translated it into first-, second-, and third-line treatment recommendations. The main objective of this contribution is to provide clinicians with a summary of the 2018 CANMAT/ISBD guideline recommendations with the addition of any new evidence for the treatment of bipolar disorder across the lifespan.

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References
1.
Geller B, Cooper T, Sun K, Zimerman B, Frazier J, Williams M . Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency. J Am Acad Child Adolesc Psychiatry. 1998; 37(2):171-8. DOI: 10.1097/00004583-199802000-00009. View

2.
Tsai S, Lee H, Chen C, Huang Y . Cognitive impairment in later life in patients with early-onset bipolar disorder. Bipolar Disord. 2007; 9(8):868-75. DOI: 10.1111/j.1399-5618.2007.00498.x. View

3.
Hirschfeld R, Calabrese J, Weissman M, Reed M, Davies M, Frye M . Screening for bipolar disorder in the community. J Clin Psychiatry. 2003; 64(1):53-9. DOI: 10.4088/jcp.v64n0111. View

4.
Jeste D, Alexopoulos G, Bartels S, Cummings J, Gallo J, Gottlieb G . Consensus statement on the upcoming crisis in geriatric mental health: research agenda for the next 2 decades. Arch Gen Psychiatry. 2003; 56(9):848-53. DOI: 10.1001/archpsyc.56.9.848. View

5.
Cyprien F, Guillaume S, Jaussent I, Lopez-Castroman J, Mercier G, Olie E . Impact of axis-I comorbidity and suicidal behavior disorders on sensitivity and specificity of the Mood Disorder Questionnaire in complex depressed inpatients. Compr Psychiatry. 2014; 55(4):876-82. DOI: 10.1016/j.comppsych.2014.02.004. View