Effect of Fractional Exhaled Nitric Oxide (F)-based Asthma Management During Pregnancy Versus Usual Care on Infant Development, Temperament, Sensory Function and Autism Signs

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2024 May 1

PMID 38691129

Authors

Olivia M Whalen

Linda E Campbell

Alison E Lane

Frini Karayanidis

Carly A Mallise

Alix J Woolard

Elizabeth G Holliday

Joerg Mattes

Adam Collison

Peter G Gibson

Vanessa E Murphy

Affiliations

Soon will be listed here.

Abstract

Conclusion: In this sample, F-guided asthma treatment during pregnancy did not improve infant developmental outcomes in the first year of life.

Trial Registration: ClinicalTrials.gov Identifier: ACTRN12613000202763.

What Is Known: • Maternal asthma during pregnancy has been associated with increased rates of neurodevelopmental conditions in offspring, including intellectual disability and autism.

What Is New: • This is the first study to examine how managing asthma during pregnancy via a F-guided algorithm or usual care affects infant developmental and behavioural outcomes. While the results of the study showed no impact of the intervention, and therefore do not support the integration of F-based management of asthma in antenatal settings for optimal infant development, they do send a positive message about the implications of active asthma management during pregnancy on infant developmental outcomes.

Citing Articles

Autism likelihood in infants born to mothers with asthma is associated with blood inflammatory gene biomarkers in pregnancy.

Murphy V, Whalen O, Williams E, Gibson P, Campbell L, Karayanidis F Brain Behav Immun Health. 2024; 40:100845.

PMID: 39247132 PMC: 11378081. DOI: 10.1016/j.bbih.2024.100845.

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