MicroRNA-181 in Cardiovascular Disease: Emerging Biomarkers and Therapeutic Targets

Overview

Journal FASEB J

Specialties Biology
Physiology

Date 2024 May 1

PMID 38690685

Authors

Bingjie Lv

Shaolin He

Peixin Li

Shijiu Jiang

Dazhu Li

Jibin Lin

Mark W Feinberg

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) is the leading cause of death worldwide. MicroRNAs (MiRNAs) have attracted considerable attention for their roles in several cardiovascular disease states, including both the physiological and pathological processes. In this review, we will briefly describe microRNA-181 (miR-181) transcription and regulation and summarize recent findings on the roles of miR-181 family members as biomarkers or therapeutic targets in different cardiovascular-related conditions, including atherosclerosis, myocardial infarction, hypertension, and heart failure. Lessons learned from these studies may provide new theoretical foundations for CVD.

Citing Articles

Role of miR-181 Family Members in Stroke: Insights into Mechanisms and Therapeutic Potential.

Braicu C, Muresanu F, Isachesku E, Bornstein N, Filipovic S, Strilciuc S Int J Mol Sci. 2025; 26(2).

PMID: 39859155 PMC: 11765211. DOI: 10.3390/ijms26020440.

Exosomes and miRNAs in Cardiovascular Diseases and Transcatheter Pulmonary Valve Replacement: Advancements, Gaps and Perspectives.

Liang R, Abudurexiti N, Wu J, Ling J, Peng Z, Yuan H Int J Mol Sci. 2025; 25(24.

PMID: 39769447 PMC: 11727898. DOI: 10.3390/ijms252413686.

References

Jin Y, Jia T, Wu X, Wang Y, Sun W, Chen Y . The predictive value of microRNA in early hypertensive disorder complicating pregnancy (HDCP). Am J Transl Res. 2021; 13(6):7288-7293. PMC: 8290685. View

Ge L, Cai Y, Ying F, Liu H, Zhang D, He Y . miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4. Oxid Med Cell Longev. 2019; 2019:1957920. PMC: 6501226. DOI: 10.1155/2019/1957920. View

Garg A, Foinquinos A, Jung M, Janssen-Peters H, Biss S, Bauersachs J . MiRNA-181a is a novel regulator of aldosterone-mineralocorticoid receptor-mediated cardiac remodelling. Eur J Heart Fail. 2020; 22(8):1366-1377. DOI: 10.1002/ejhf.1813. View

Zheng Y, Wang L, Niu F, Liu Y, Feng L . MMP-9 and miR-181a-5p in serum and placenta are associated with adverse outcomes of patients with severe preeclampsia and their infants. J Hum Hypertens. 2022; 36(12):1072-1077. DOI: 10.1038/s41371-021-00643-z. View

Li F, Zhang C, Luo X, Peng J, Yang T . Involvement of the MiR-181b-5p/HMGB1 Pathway in Ang II-induced Phenotypic Transformation of Smooth Muscle Cells in Hypertension. Aging Dis. 2019; 10(2):231-248. PMC: 6457049. DOI: 10.14336/AD.2018.0510. View

Yuan L, Fan L, Li Q, Cui W, Wang X, Zhang Z . Inhibition of miR-181b-5p protects cardiomyocytes against ischemia/reperfusion injury by targeting AKT3 and PI3KR3. J Cell Biochem. 2019; 120(12):19647-19659. DOI: 10.1002/jcb.29271. View

Gao Z, Wang L, Wang J, Yang F, Qu J . Molecular mechanism of miR-181b in heart disease due to pregnancy-induced hypertension syndrome. Exp Ther Med. 2017; 14(4):2953-2959. PMC: 5585881. DOI: 10.3892/etm.2017.4882. View

Zhong X, Ma X, Zhang L, Li Y, Li Y, He R . MIAT promotes proliferation and hinders apoptosis by modulating miR-181b/STAT3 axis in ox-LDL-induced atherosclerosis cell models. Biomed Pharmacother. 2017; 97:1078-1085. DOI: 10.1016/j.biopha.2017.11.052. View

Zhou H, Yang D, Cheng H, McCoy M, Perez-Cremades D, Haemmig S . miR-181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway. FASEB J. 2022; 36(6):e22353. PMC: 9167053. DOI: 10.1096/fj.202200046R. View

10.

Wang Z, Li C, Sun X, Li Z, Li J, Wang L . Hypermethylation of miR-181b in monocytes is associated with coronary artery disease and promotes M1 polarized phenotype via PIAS1-KLF4 axis. Cardiovasc Diagn Ther. 2020; 10(4):738-751. PMC: 7487404. DOI: 10.21037/cdt-20-407. View

11.

Heath J, Fernandez Esmerats J, Khambouneheuang L, Kumar S, Simmons R, Jo H . Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3. Cardiovasc Eng Technol. 2017; 9(2):141-150. PMC: 5568995. DOI: 10.1007/s13239-017-0296-z. View

12.

Jackson K, Marques F, Watson A, Palma-Rigo K, Nguyen-Huu T, Morris B . A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice. Hypertension. 2013; 62(4):775-81. DOI: 10.1161/HYPERTENSIONAHA.113.01701. View

13.

Zhong W, Yang J, Cao Q, Huan X . Association between miR-181b and PKG 1 in myocardial hypertrophy and its clinical implications. Exp Ther Med. 2015; 10(3):857-862. PMC: 4533127. DOI: 10.3892/etm.2015.2647. View

14.

Holliday C, Ankeny R, Jo H, Nerem R . Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells. Am J Physiol Heart Circ Physiol. 2011; 301(3):H856-67. PMC: 3191100. DOI: 10.1152/ajpheart.00117.2011. View

15.

Jankauskas S, Mone P, Avvisato R, Varzideh F, De Gennaro S, Salemme L . miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction. Mech Ageing Dev. 2023; 212:111818. PMC: 10330534. DOI: 10.1016/j.mad.2023.111818. View

16.

Chen T, Battsengel S, Kuo C, Pan L, Lin Y, Yao C . Stem cells rescue cardiomyopathy induced by P. gingivalis-LPS via miR-181b. J Cell Physiol. 2017; 233(8):5869-5876. DOI: 10.1002/jcp.26386. View

17.

Marques F, Campain A, Tomaszewski M, Zukowska-Szczechowska E, Yang Y, Charchar F . Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs. Hypertension. 2011; 58(6):1093-8. DOI: 10.1161/HYPERTENSIONAHA.111.180729. View

18.

Du X, Lu J, Sha Y . MiR-181a inhibits vascular inflammation induced by ox-LDL via targeting TLR4 in human macrophages. J Cell Physiol. 2018; 233(10):6996-7003. DOI: 10.1002/jcp.26622. View

19.

Seeger T, Haffez F, Fischer A, Koehl U, Leistner D, Seeger F . Immunosenescence-associated microRNAs in age and heart failure. Eur J Heart Fail. 2012; 15(4):385-93. DOI: 10.1093/eurjhf/hfs184. View

20.

Morrison K, Solly E, Shemesh T, Psaltis P, Nicholls S, Brown A . Elevated HDL-bound miR-181c-5p level is associated with diabetic vascular complications in Australian Aboriginal people. Diabetologia. 2021; 64(6):1402-1411. DOI: 10.1007/s00125-021-05414-6. View