Nutritional Therapy Bridges the Critical Cut-off Point for the Closed-loop Role of Type 2 Diabetes and Bone Homeostasis: A Narrative Review

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 May 1

PMID 38689978

Authors

Jia Zeng

Ying Qian

Jizhuo Yang

Xinqiang Chen

Chuanwen Fu

Zhuohang Che

Yuemei Feng

Jianzhong Yin

Affiliations

Soon will be listed here.

Abstract

Currently, osteoporosis-related fractures become the most cutting-edge problem of diabetes-related complications. Rational diet is not only the basis of glycemic management in type 2 diabetes patients, but also the direction of diabetic bone health. This review highlights the importance of micronutrient supplementation (including calcium, magnesium, zinc, vitamin D, vitamin K, and vitamin C) for patients with T2DM, as well as describing the constructive intermediary role of gut flora between T2DM and bone through nutrients predominantly high in dietary fiber. In addition, it is recommended to combine the Mediterranean dietary pattern with other diversified management approaches to prevent OP. Therefore, this provides a theoretical basis for the potential role of islet -cells in promoting bone health.

Citing Articles

Risk factors for osteoporosis in elderly patients with type 2 diabetes: A protocol for systematic review and meta-analysis.

Su W, Jia H, Yang L, Zhang J, Wei Z, Tsikwa P PLoS One. 2025; 20(2):e0319602.

PMID: 40014597 PMC: 11867315. DOI: 10.1371/journal.pone.0319602.

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