Socialized Mitochondria: Mitonuclear Crosstalk in Stress

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2024 Apr 30

PMID 38689084

Authors

Kyung Hwa Kim

Cho Bi Lee

Affiliations

Soon will be listed here.

Abstract

Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling organelles that are involved in intracellular interactions with other organelles. Remarkably, stressed mitochondria appear to induce a beneficial response that restores mitochondrial function and cellular homeostasis. These mitochondrial stress-centered signaling pathways have been rapidly elucidated in multiple organisms. In this review, we examine current perspectives on how mitochondria communicate with the rest of the cell, highlighting mitochondria-to-nucleus (mitonuclear) communication under various stresses. Our understanding of mitochondria as signaling organelles may provide new insights into disease susceptibility and lifespan extension.

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