The Functions of Hydrogen Sulfide on the Urogenital System of Both Males and Females: from Inception to the Present

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 2024 Apr 30

PMID 38689070

Authors

Sajad Salehiyeh

Ahmad Faisal Faiz

Mohammad Manzourolhojeh

Amir Mohammad Bagheri

Keivan Lorian

Affiliations

Soon will be listed here.

Abstract

Hydrogen sulfide (HS) is known as a chemical gas in nature with both enzymatic and non-enzymatic biosynthesis in different human organs. A couple of studies have demonstrated the function of HS in regulating the homeostasis of the human body. Additionally, they have shown its synthesis, measurement, chemistry, protective effects, and interaction in various aspects of scientific evidence. Furthermore, many researches have demonstrated the beneficial impacts of HS on genital organs and systems. According to various studies, it is recognized that HS-producing enzymes and the endogenous production of HS are expressed in male and female reproductive systems in different mammalian species. The main goal of this comprehensive review is to assess the potential therapeutic impacts of this gasotransmitter in the male and female urogenital system and find underlying mechanisms of this agent. This narrative review investigated the articles that were published from the 1970s to 2022. The review's primary focus is the impacts of HS on the male and female urogenital system. Medline, CINAHL, PubMed, and Google scholar databases were searched. Keywords used in this review were "Hydrogen sulfide," "HS," "urogenital system," and "urogenital tract". Numerous studies have demonstrated the therapeutic and protective effects of sodium hydrosulfide (Na-HS) as an HS donor on male and female infertility disorders. Furthermore, it has been observed that HS plays a significant role in improving different diseases such as ameliorating sperm parameters. The specific localization of HS enzymes in the urogenital system provides an excellent opportunity to comprehend its function and role in various disorders related to this system. It is noteworthy that HS has been demonstrated to be produced in endocrine organs and exhibit diverse activities. Moreover, it is important to recognize that alterations in HS biosynthesis are closely linked to endocrine disorders. Therefore, hormones can be pivotal in regulating HS production, and HS synthesis pathways may aid in establishing novel therapeutic strategies. HS possesses pharmacological effects on essential disorders, such as anti-inflammation, anti-apoptosis, and anti-oxidant activities, which render it a valuable therapeutic agent for human urogenital disease. Furthermore, this agent shows promise in ameliorating the detrimental effects of various male and female diseases. Despite the limited clinical research, studies have demonstrated that applying HS as an anti-oxidant source could ameliorate adverse effects of different conditions in the urogenital system. More clinical studies are required to confirm the role of this component in clinical settings.

References

Abdel Moneim A, Othman M, Aref A . Azadirachta indica attenuates cisplatin-induced nephrotoxicity and oxidative stress. Biomed Res Int. 2014; 2014:647131. PMC: 4137610. DOI: 10.1155/2014/647131. View

Abdellatief S, Galal A, Farouk S, Abdel-Daim M . Ameliorative effect of parsley oil on cisplatin-induced hepato-cardiotoxicity: A biochemical, histopathological, and immunohistochemical study. Biomed Pharmacother. 2016; 86:482-491. DOI: 10.1016/j.biopha.2016.12.038. View

Abe K, Kimura H . The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996; 16(3):1066-71. PMC: 6578817. View

Agis-Torres A, Recio P, Lopez-Oliva M, Martinez M, Victoria Barahona M, Benedito S . Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission. Sci Rep. 2018; 8(1):4711. PMC: 5856743. DOI: 10.1038/s41598-018-22934-1. View

Al-Jaghbeer M, DeAlmeida D, Bilderback A, Ambrosino R, Kellum J . Clinical Decision Support for In-Hospital AKI. J Am Soc Nephrol. 2017; 29(2):654-660. PMC: 5791078. DOI: 10.1681/ASN.2017070765. View

Andersson K . Clinical pharmacology of potassium channel openers. Pharmacol Toxicol. 1992; 70(4):244-54. DOI: 10.1111/j.1600-0773.1992.tb00466.x. View

Andersson K, Arner A . Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 2004; 84(3):935-86. DOI: 10.1152/physrev.00038.2003. View

Benavides G, Squadrito G, Mills R, Patel H, Isbell T, Patel R . Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A. 2007; 104(46):17977-82. PMC: 2084282. DOI: 10.1073/pnas.0705710104. View

Bigagli E, Luceri C, De Angioletti M, Chegaev K, DAmbrosio M, Riganti C . New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations. Invest New Drugs. 2018; 36(6):985-998. DOI: 10.1007/s10637-018-0590-0. View

10.

Brading A . Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J Physiol. 2005; 570(Pt 1):13-22. PMC: 1464291. DOI: 10.1113/jphysiol.2005.097311. View

11.

Bucci M, Mirone V, Di Lorenzo A, Vellecco V, Roviezzo F, Brancaleone V . Hydrogen sulphide is involved in testosterone vascular effect. Eur Urol. 2008; 56(2):378-83. DOI: 10.1016/j.eururo.2008.05.014. View

12.

Buckner S, Milicic I, Daza A, Scott V, Sullivan J, Brioni J . Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig and human detrusor. Eur J Pharmacol. 2000; 400(2-3):287-95. DOI: 10.1016/s0014-2999(00)00388-5. View

13.

Cao X, Zhang W, Moore P, Bian J . Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity. Int J Mol Sci. 2019; 20(2). PMC: 6359127. DOI: 10.3390/ijms20020313. View

14.

Chen G, Chen H, Wang C, Peng Y, Sun L, Liu H . Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts. PLoS One. 2012; 7(3):e33626. PMC: 3314672. DOI: 10.1371/journal.pone.0033626. View

15.

Chen X, Xu W, Wang Y, Luo H, Quan S, Zhou J . Hydrogen sulfide reduces kidney injury due to urinary-derived sepsis by inhibiting NF-κB expression, decreasing TNF-α levels and increasing IL-10 levels. Exp Ther Med. 2014; 8(2):464-470. PMC: 4079422. DOI: 10.3892/etm.2014.1781. View

16.

Chevalier R, Forbes M, Thornhill B . Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int. 2009; 75(11):1145-1152. DOI: 10.1038/ki.2009.86. View

17.

Christ G, Hodges S . Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction. Br J Pharmacol. 2006; 147 Suppl 2:S41-55. PMC: 1751499. DOI: 10.1038/sj.bjp.0706627. View

18.

Cirino G, Fusco F, Imbimbo C, Mirone V . Pharmacology of erectile dysfunction in man. Pharmacol Ther. 2006; 111(2):400-23. DOI: 10.1016/j.pharmthera.2005.10.011. View

19.

Dasari S, Tchounwou P . Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014; 740:364-78. PMC: 4146684. DOI: 10.1016/j.ejphar.2014.07.025. View

20.

Djudjaj S, Chatziantoniou C, Raffetseder U, Guerrot D, Dussaule J, Boor P . Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury. J Pathol. 2012; 228(3):286-99. DOI: 10.1002/path.4076. View