Effect of Leptin Receptor Q223R Polymorphism on Clostridioides Difficile Infection-Induced Macrophage Migration Inhibitory Factor Production

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2024 Apr 30

PMID 38687212

Authors

Ann M Mathew

Alexander Huber

Rowis D Sous

Kristin N Weghorn

Margaret V Powers-Fletcher

Shinsmon Jose

Rajat Madan

Affiliations

Soon will be listed here.

Abstract

Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF production and its association with a common genetic variant in leptin receptor (LEPR) using blood from patients with CDI. We found highest plasma MIF early after C difficile exposure and in individuals who express mutant/derived LEPR. Our data suggest that early-phase CDI provides a possible window of opportunity in which MIF targeting, potentially in combination with LEPR genotype, could have therapeutic utility.

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