Rethinking the Application of Nanoparticles in Women's Reproductive Health and Assisted Reproduction

Overview

Journal Nanomedicine (Lond)

Specialty Biotechnology

Date 2024 Apr 30

PMID 38686941

Authors

Emily Hs Davis

Celine Jones

Kevin Coward

Affiliations

Soon will be listed here.

Abstract

Nanoparticles and nanotechnology may present opportunities to revolutionize the prevention, treatment and diagnosis of a range of reproductive health conditions in women. These technologies are also used to improve outcomes of assisted reproductive technology. We highlight a range of these potential clinical uses of nanoparticles for polycystic ovary syndrome, endometriosis, uterine fibroids and sexually transmitted infections, considering and studies along with clinical trials. In addition, we discuss applications of nanoparticles in assisted reproductive technology, including sperm loading, gamete and embryo preservation and preventing preterm birth. Finally, we present some of the concerns associated with the medical use of nanoparticles, identifying routes for further exploration before nanoparticles can be applied to women's reproductive health in the clinic.

References

Marfatia Y, Pandya I, Mehta K . Condoms: Past, present, and future. Indian J Sex Transm Dis AIDS. 2015; 36(2):133-9. PMC: 4660551. DOI: 10.4103/0253-7184.167135. View

Zhao M, Sun Y, Fu G, Du Y, Chen F, Yuan H . Gene therapy of endometriosis introduced by polymeric micelles with glycolipid-like structure. Biomaterials. 2011; 33(2):634-43. DOI: 10.1016/j.biomaterials.2011.09.077. View

de Jong W, Borm P . Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine. 2008; 3(2):133-49. PMC: 2527668. DOI: 10.2147/ijn.s596. View

Liu L, Johnson H, Cousens S, Perin J, Scott S, Lawn J . Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012; 379(9832):2151-61. DOI: 10.1016/S0140-6736(12)60560-1. View

Pal Z, Urban E, Dosa E, Pal A, Nagy E . Biofilm formation on intrauterine devices in relation to duration of use. J Med Microbiol. 2005; 54(Pt 12):1199-1203. DOI: 10.1099/jmm.0.46197-0. View

de Almeida Monteiro Melo Ferraz M, Fujihara M, Nagashima J, Noonan M, Inoue-Murayama M, Songsasen N . Follicular extracellular vesicles enhance meiotic resumption of domestic cat vitrified oocytes. Sci Rep. 2020; 10(1):8619. PMC: 7248092. DOI: 10.1038/s41598-020-65497-w. View

Liu M, Xia Y, Wu X, Huang J, Guo X . Loop-mediated isothermal amplification of Neisseria gonorrhoeae porA pseudogene: a rapid and reliable method to detect gonorrhea. AMB Express. 2017; 7(1):48. PMC: 5323338. DOI: 10.1186/s13568-017-0349-6. View

Sun J, Mao B, Wu Z, Jiao X, Wang Y, Lu Y . Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China: A nested case-control study. Front Public Health. 2022; 10:946439. PMC: 9381958. DOI: 10.3389/fpubh.2022.946439. View

Murji A, Qin J, Hermanus T, Morris L, Georgiev I . Elicitation of Neutralizing Antibody Responses to HIV-1 Immunization with Nanoparticle Vaccine Platforms. Viruses. 2021; 13(7). PMC: 8310022. DOI: 10.3390/v13071296. View

10.

Khalaj K, Miller J, Lingegowda H, Fazleabas A, Young S, Lessey B . Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature. JCI Insight. 2019; 4(18). PMC: 6795291. DOI: 10.1172/jci.insight.128846. View

11.

Chen X, Zhou Q, Yuan W, Shi Y, Dong S, Luo X . Visual and rapid identification of and using multiplex loop-mediated isothermal amplification and a gold nanoparticle-based lateral flow biosensor. Front Cell Infect Microbiol. 2023; 13:1067554. PMC: 10011439. DOI: 10.3389/fcimb.2023.1067554. View

12.

Davoodi Asl F, Sahraei S, Kalhor N, Fazaeli H, Sheykhhasan M, Soleimani Moud S . Promising effects of exosomes from menstrual blood-derived mesenchymal stem cells on endometriosis. Reprod Biol. 2023; 23(3):100788. DOI: 10.1016/j.repbio.2023.100788. View

13.

Khosla K, Wang Y, Hagedorn M, Qin Z, Bischof J . Gold Nanorod Induced Warming of Embryos from the Cryogenic State Enhances Viability. ACS Nano. 2017; 11(8):7869-7878. DOI: 10.1021/acsnano.7b02216. View

14.

Lee H, Lee H, Lee J, Chang Y, Woo S . Ultrasmall superparamagnetic iron oxides enhanced MR imaging in rats with experimentally induced endometriosis. Magn Reson Imaging. 2012; 30(6):860-8. DOI: 10.1016/j.mri.2012.02.020. View

15.

Horne A, Saunders P, Abokhrais I, Hogg L . Top ten endometriosis research priorities in the UK and Ireland. Lancet. 2017; 389(10085):2191-2192. DOI: 10.1016/S0140-6736(17)31344-2. View

16.

Notario-Perez F, Cazorla-Luna R, Martin-Illana A, Galante J, Ruiz-Caro R, Sarmento B . Influence of Plasticizers on the pH-Dependent Drug Release and Cellular Interactions of Hydroxypropyl Methylcellulose/Zein Vaginal Anti-HIV Films Containing Tenofovir. Biomacromolecules. 2021; 22(2):938-948. DOI: 10.1021/acs.biomac.0c01609. View

17.

Brohi R, Wang L, Talpur H, Wu D, Khan F, Bhattarai D . Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review. Front Pharmacol. 2017; 8:606. PMC: 5591883. DOI: 10.3389/fphar.2017.00606. View

18.

Sun I, Ahn C, Kim K, Emelianov S . Photoacoustic imaging of cancer cells with glycol-chitosan-coated gold nanoparticles as contrast agents. J Biomed Opt. 2019; 24(12):1-5. PMC: 6680094. DOI: 10.1117/1.JBO.24.12.121903. View

19.

Yah C, Simate G, Hlangothi P, Somai B . Nanotechnology and the future of condoms in the prevention of sexually transmitted infections. Ann Afr Med. 2018; 17(2):49-57. PMC: 5875119. DOI: 10.4103/aam.aam_32_17. View

20.

Abdallah A, El-Ghannam M, Hasan A, Mohammad L, Mesalam N, Alsayed R . Selenium Nanoparticles Modulate Steroidogenesis-Related Genes and Improve Ovarian Functions via Regulating Androgen Receptors Expression in Polycystic Ovary Syndrome Rat Model. Biol Trace Elem Res. 2023; 201(12):5721-5733. PMC: 10620277. DOI: 10.1007/s12011-023-03616-0. View