[Research Advances of Mesenchymal Stem Cell in Allergic Rhinitis]

Overview

Journal Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi

Specialty Otorhinolaryngology

Date 2024 Apr 30

PMID 38686485

Authors

Wenjin Li

Yanjie Wang

Fengli Cheng

Xueping Qi

Yunfang An

Changqing Zhao

Affiliations

Soon will be listed here.

Abstract

Allergic rhinitis is a chronic nasal mucosal inflammation characterized by upper airway hyperresponsiveness, involving a variety of immune cells and inflammatory mediators. Drugs, immunotherapy, and surgical operation are the principal treatments at present. The study found that mesenchymal stem cells have the ability of immune regulation and have a promising clinical application in the treatment of allergic rhinitis. In this review, the action mechanism of mesenchymal stem cells, the immunomodulatory effect of mesenchymal stem cells on the key cells of allergic rhinitis, and the challenges of clinical application are reviewed, to provide new directions for the treatment of allergic rhinitis.

References

Zou B, Zhuang R, Sun X, Liang J . Analysis of the expression changes of IL-17+ γδ T cells and Treg cells in bone marrow mesenchymal stem cells targeted therapy for allergic rhinitis. Eur Rev Med Pharmacol Sci. 2021; 25(7):2858-2865. DOI: 10.26355/eurrev_202104_25539. View

Cho B, Kim J, Ha D, Yi Y . Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis. Stem Cell Res Ther. 2018; 9(1):187. PMC: 6042362. DOI: 10.1186/s13287-018-0939-5. View

Lee H, Jung H, Kim D . IDO and CD40 May Be Key Molecules for Immunomodulatory Capacity of the Primed Tonsil-Derived Mesenchymal Stem Cells. Int J Mol Sci. 2021; 22(11). PMC: 8198434. DOI: 10.3390/ijms22115772. View

Zhong H, Fan X, Fang S, Lin Y, Wen W, Fu Q . Human pluripotent stem cell-derived mesenchymal stem cells prevent chronic allergic airway inflammation via TGF-β1-Smad2/Smad3 signaling pathway in mice. Mol Immunol. 2019; 109:51-57. DOI: 10.1016/j.molimm.2019.02.017. View

Khare D, Or R, Resnick I, Barkatz C, Almogi-Hazan O, Avni B . Mesenchymal Stromal Cell-Derived Exosomes Affect mRNA Expression and Function of B-Lymphocytes. Front Immunol. 2019; 9:3053. PMC: 6308164. DOI: 10.3389/fimmu.2018.03053. View

Isik S, Karaman M, Adan A, Kiray M, Bagriyanik H, Caglayan Sozmen S . Intraperitoneal mesenchymal stem cell administration ameliorates allergic rhinitis in the murine model. Eur Arch Otorhinolaryngol. 2016; 274(1):197-207. DOI: 10.1007/s00405-016-4166-3. View

Zhao N, Liu Y, Liang H, Jiang X . Bone marrow-derived mesenchymal stem cells reduce immune reaction in a mouse model of allergic rhinitis. Am J Transl Res. 2017; 8(12):5628-5636. PMC: 5209513. View

Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F . Human mesenchymal stem cells modulate B-cell functions. Blood. 2005; 107(1):367-72. DOI: 10.1182/blood-2005-07-2657. View

Vieujean S, Loly J, Boutaffala L, Meunier P, Reenaers C, Briquet A . Mesenchymal Stem Cell Injection in Crohn's Disease Strictures: A Phase I-II Clinical Study. J Crohns Colitis. 2021; 16(3):506-510. DOI: 10.1093/ecco-jcc/jjab154. View

10.

Fu Y, Kong Y, Li J, Wang Y, Li M, Wang Y . Mesenchymal stem cells combined with traditional Chinese medicine (qi-fang-bi-min-tang) alleviates rodent allergic rhinitis. J Cell Biochem. 2019; 121(2):1541-1551. DOI: 10.1002/jcb.29389. View

11.

Guo Y, Peng Y, Zeng H, Chen G . Progress in Mesenchymal Stem Cell Therapy for Ischemic Stroke. Stem Cells Int. 2021; 2021:9923566. PMC: 8219421. DOI: 10.1155/2021/9923566. View

12.

Kavuzlu A, Tatar E, Karagoz T, Pinarli F, Tatar I, Bayir O . The effects of the stem cell on ciliary regeneration of injured rabbit sinonasal epithelium. Eur Arch Otorhinolaryngol. 2017; 274(8):3057-3064. DOI: 10.1007/s00405-017-4595-7. View

13.

Ma S, Zhao N, Cui L, Li Y, Zhang H, Wang J . Therapeutic Effects of Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells on a Murine Model of Acute Type-2-Dominated Airway Inflammation. Stem Cell Rev Rep. 2022; 18(8):2939-2951. DOI: 10.1007/s12015-022-10389-x. View

14.

Panes J, Garcia-Olmo D, Van Assche G, Colombel J, Reinisch W, Baumgart D . Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease. Gastroenterology. 2017; 154(5):1334-1342.e4. DOI: 10.1053/j.gastro.2017.12.020. View

15.

Zhao K, Lin R, Fan Z, Chen X, Wang Y, Huang F . Mesenchymal stromal cells plus basiliximab, calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter, randomized, phase 3, open-label trial. J Hematol Oncol. 2022; 15(1):22. PMC: 8900437. DOI: 10.1186/s13045-022-01240-4. View

16.

Campo A, Gonzalez-Ruiz J, Andreu E, Alcaide A, Ocon M, De-Torres J . Endobronchial autologous bone marrow-mesenchymal stromal cells in idiopathic pulmonary fibrosis: a phase I trial. ERJ Open Res. 2021; 7(2). PMC: 8236617. DOI: 10.1183/23120541.00773-2020. View

17.

Park I, Kim D, Kim J, Bae J, Kim E, Yoo S . Increased Anti-Allergic Effects of Secretome of Low-Level Light Treated Tonsil-Derived Mesenchymal Stem Cells in Allergic Rhinitis Mouse Model. Am J Rhinol Allergy. 2021; 36(2):261-268. DOI: 10.1177/19458924211053762. View

18.

Zhao A, Yang Z, Sun R, Grinchuk V, Netzel-Arnett S, Anglin I . SerpinB2 is critical to Th2 immunity against enteric nematode infection. J Immunol. 2013; 190(11):5779-87. PMC: 4068334. DOI: 10.4049/jimmunol.1200293. View

19.

Lu Z, Meng S, Chang W, Fan S, Xie J, Guo F . Mesenchymal stem cells activate Notch signaling to induce regulatory dendritic cells in LPS-induced acute lung injury. J Transl Med. 2020; 18(1):241. PMC: 7298963. DOI: 10.1186/s12967-020-02410-z. View

20.

Lin T, Chang T, Huang H . Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Attenuate Mast Cell Activation. Antioxidants (Basel). 2022; 11(11). PMC: 9686796. DOI: 10.3390/antiox11112279. View