HPLC-Based Automated Synthesis and Purification of Carbohydrates

Overview

Journal Chemistry

Specialty Chemistry

Date 2024 Apr 29

PMID 38684455

Authors

Gustavo A Kashiwagi

Laura Petrosilli

Samira Escopy

Luigi Lay

Keith J Stine

Cristina De Meo

Alexei V Demchenko

Affiliations

Soon will be listed here.

Abstract

Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.

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