Advancements in Culture Technology of Adipose-derived Stromal/stem Cells: Implications for Diabetes and Its Complications

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2024 Apr 29

PMID 38681772

Authors

Yinze Shi

Xueyang Yang

Jie Min

Wen Kong

Xiang Hu

Jiaoyue Zhang

Lulu Chen

Affiliations

Soon will be listed here.

Abstract

Stem cell-based therapies exhibit considerable promise in the treatment of diabetes and its complications. Extensive research has been dedicated to elucidate the characteristics and potential applications of adipose-derived stromal/stem cells (ASCs). Three-dimensional (3D) culture, characterized by rapid advancements, holds promise for efficacious treatment of diabetes and its complications. Notably, 3D cultured ASCs manifest enhanced cellular properties and functions compared to traditional monolayer-culture. In this review, the factors influencing the biological functions of ASCs during culture are summarized. Additionally, the effects of 3D cultured techniques on cellular properties compared to two-dimensional culture is described. Furthermore, the therapeutic potential of 3D cultured ASCs in diabetes and its complications are discussed to provide insights for future research.

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