Exploring the Role of Gut Microbiota in Patients with Alopecia Areata

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Apr 27

PMID 38673841

Authors

Ji Hae Lee

Ji Hae Shin

Ji Yoon Kim

Hyun Jeong Ju

Gyong Moon Kim

Affiliations

Soon will be listed here.

Abstract

Imbalances in gut microbiota reportedly contribute to the development of autoimmune diseases, but the association between the etiopathogenesis of alopecia areata (AA) and gut microbial dysbiosis remains unclear. This cross-sectional study was conducted to identify and compare the composition of the gut microbiome in patients affected by AA and those in a healthy control (HC) group, and to investigate possible bacterial biomarkers for the disease. Fecal samples were collected from 19 AA patients and 20 HCs to analyze the relationship with fecal bacteria. The three major genera constituting the gut microbiome of AA patients were , , and . The alpha diversity of the AA group was not statistically significant different from that of the HC group. However, bacterial community composition in the AA group was significantly different from that of HC group according to Jensen-Shannon dissimilarities. In patients with AA, we found an enriched presence of the genera and compared to the HC group ( < 0.05), whereas were less prevalent ( < 0.05). The gut microbiota of AA patients was distinct from those of the HC group. Our findings suggest a possible involvement of gut microbiota in in the as-yet-undefined pathogenesis of AA.

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References

Tie Y, Huang Y, Chen R, Li L, Chen M, Zhang S . Current insights on the roles of gut microbiota in inflammatory bowel disease-associated extra-intestinal manifestations: pathophysiology and therapeutic targets. Gut Microbes. 2023; 15(2):2265028. PMC: 10572083. DOI: 10.1080/19490976.2023.2265028. View

Ley R, Lozupone C, Hamady M, Knight R, Gordon J . Worlds within worlds: evolution of the vertebrate gut microbiota. Nat Rev Microbiol. 2008; 6(10):776-88. PMC: 2664199. DOI: 10.1038/nrmicro1978. View

Chen Y, Ho H, Tseng C, Lai Z, Shieh J, Wu C . Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients. Exp Dermatol. 2018; 27(12):1336-1343. DOI: 10.1111/exd.13786. View

Rangu S, Lee J, Hu W, Bittinger K, Castelo-Soccio L . Understanding the Gut Microbiota in Pediatric Patients with Alopecia Areata and their Siblings: A Pilot Study. JID Innov. 2021; 1(4):100051. PMC: 8659389. DOI: 10.1016/j.xjidi.2021.100051. View

Fukuyama M, Ito T, Ohyama M . Alopecia areata: Current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines. J Dermatol. 2021; 49(1):19-36. DOI: 10.1111/1346-8138.16207. View

Smith P, Howitt M, Panikov N, Michaud M, Gallini C, Bohlooly-Y M . The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013; 341(6145):569-73. PMC: 3807819. DOI: 10.1126/science.1241165. View

Qin J, Li R, Raes J, Arumugam M, Burgdorf K, Manichanh C . A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010; 464(7285):59-65. PMC: 3779803. DOI: 10.1038/nature08821. View

Amiri P, Hosseini S, Ghaffari S, Tutunchi H, Ghaffari S, Mosharkesh E . Role of Butyrate, a Gut Microbiota Derived Metabolite, in Cardiovascular Diseases: A comprehensive narrative review. Front Pharmacol. 2022; 12:837509. PMC: 8847574. DOI: 10.3389/fphar.2021.837509. View

McElwee K, Niiyama S, Freyschmidt-Paul P, Wenzel E, Kissling S, Sundberg J . Dietary soy oil content and soy-derived phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice. Exp Dermatol. 2003; 12(1):30-6. DOI: 10.1034/j.1600-0625.2003.120104.x. View

10.

Lee S, Yoon S, Jung Y, Kim N, Min U, Chun J . Emotional well-being and gut microbiome profiles by enterotype. Sci Rep. 2020; 10(1):20736. PMC: 7691370. DOI: 10.1038/s41598-020-77673-z. View

11.

Hamer H, Jonkers D, Venema K, Vanhoutvin S, Troost F, Brummer R . Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2007; 27(2):104-19. DOI: 10.1111/j.1365-2036.2007.03562.x. View

12.

Claesson M, Jeffery I, Conde S, Power S, OConnor E, Cusack S . Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012; 488(7410):178-84. DOI: 10.1038/nature11319. View

13.

Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett W . Metagenomic biomarker discovery and explanation. Genome Biol. 2011; 12(6):R60. PMC: 3218848. DOI: 10.1186/gb-2011-12-6-r60. View

14.

Brestoff J, Artis D . Commensal bacteria at the interface of host metabolism and the immune system. Nat Immunol. 2013; 14(7):676-84. PMC: 4013146. DOI: 10.1038/ni.2640. View

15.

Langille M, Zaneveld J, Caporaso J, McDonald D, Knights D, Reyes J . Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol. 2013; 31(9):814-21. PMC: 3819121. DOI: 10.1038/nbt.2676. View

16.

Gilhar A, Etzioni A, Paus R . Alopecia areata. N Engl J Med. 2012; 366(16):1515-25. DOI: 10.1056/NEJMra1103442. View

17.

Rebello D, Wang E, Yen E, A Lio P, Kelly C . Hair Growth in Two Alopecia Patients after Fecal Microbiota Transplant. ACG Case Rep J. 2017; 4:e107. PMC: 5599691. DOI: 10.14309/crj.2017.107. View

18.

Sobolewska-Wlodarczyk A, Wlodarczyk M, Fichna J, Wisniewska-Jarosinska M . Alopecia areata in patients with inflammatory bowel disease: an overview. Folia Med Cracov. 2016; 56(1):5-12. View

19.

Zhao F, Feng J, Li J, Zhao L, Liu Y, Chen H . Alterations of the Gut Microbiota in Hashimoto's Thyroiditis Patients. Thyroid. 2018; 28(2):175-186. DOI: 10.1089/thy.2017.0395. View

20.

Yoon S, Ha S, Kwon S, Lim J, Kim Y, Seo H . Introducing EzBioCloud: a taxonomically united database of 16S rRNA gene sequences and whole-genome assemblies. Int J Syst Evol Microbiol. 2016; 67(5):1613-1617. PMC: 5563544. DOI: 10.1099/ijsem.0.001755. View