Impact of ZrO Content on the Formation of Sr-Enriched Phosphates in AlO/ZrO Nanocomposites for Bone Tissue Engineering

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2024 Apr 27

PMID 38673250

Authors

Fabio Caixeta Nunes

Sarah Ingrid Pinto Santos

Luiz Alberto Colnago

Peter Hammer

Julieta Adriana Ferreira

Carlos Eduardo Ambrosio

Eliria Maria Jesus Agnolon Pallone

Affiliations

Soon will be listed here.

Abstract

This study investigates the profound impact of the ZrO inclusion volume on the characteristics of AlO/ZrO nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15 vol% ZrO, subjecting them to chemical surface treatment for enhanced calcium phosphate deposition sites. Biomimetic coating with Sr-enriched simulated body fluid (SBF) further enhanced the bioactivity of nanocomposites. While the ZrO concentration heightened the oxygen availability on nanocomposite surfaces, the quantity of Sr-containing phosphate was comparatively less influenced than the formation of calcium phosphate phases. Notably, the coated nanocomposites exhibited a high cell viability and no toxicity, signifying their potential in bone tissue engineering. Overall, these findings contribute to the development of regenerative biomaterials, holding promise for enhancing bone regeneration therapies.

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