Association Between Being Breastfed in Infancy and Adult Colorectal Cancer Risk Among Japanese Men and Women

Overview

Journal Sci Rep

Specialty Science

Date 2024 Apr 26

PMID 38671142

Authors

Yuko Minami

Seiki Kanemura

Jun Kusaka

Makoto Kinouchi

Shinichi Suzuki

Hajime Iwasashi

Yoshikazu Nishino

Yoichiro Kakugawa

Koh Miura

Affiliations

Soon will be listed here.

Abstract

It has been postulated that being breastfed in infancy affects not only health status in childhood but also disease risk in adulthood. To investigate the association of being breastfed with the risks of adult colorectal cancer and benign tumor, we conducted a case-control study including 1190 colorectal cancer and 1585 benign tumor cases and 5301 controls, admitted to a single hospital in Miyagi Prefecture, Japan, between 1997 and 2013. History of having been breastfed was assessed using a self-administered questionnaire, and odds ratios (ORs) were estimated using unconditional logistic regression. There was no association between being breastfed and colorectal cancer risk (breastfed versus formula-only fed, OR = 1.21; 95% CI 0.87-1.67). There was also no association with the risk of benign tumor (OR = 1.04). On the other hand, analyses stratified by sex and birth year found heterogeneous associations. Women born after 1950 who had been breastfed tended to have increased risks of colorectal cancer (OR = 1.58) and benign tumor (OR = 1.51) relative to those who had been formula-only fed, although not statistically significant. In men born after 1950, being breastfed was associated with a significantly decreased risk of benign tumor (OR = 0.57; 95% CI 0.33-0.98).

References

Yang T, Cairns B, Green J, Reeves G, Floud S, Bradbury K . Adult cancer risk in women who were breastfed as infants: large UK prospective study. Eur J Epidemiol. 2019; 34(9):863-870. PMC: 6759744. DOI: 10.1007/s10654-019-00528-z. View

Siegel R, Fedewa S, Anderson W, Miller K, Ma J, Rosenberg P . Colorectal Cancer Incidence Patterns in the United States, 1974-2013. J Natl Cancer Inst. 2017; 109(8). PMC: 6059239. DOI: 10.1093/jnci/djw322. View

Rogers I, Emmett P, Gunnell D, Dunger D, Holly J . Milk as a food for growth? The insulin-like growth factors link. Public Health Nutr. 2006; 9(3):359-68. DOI: 10.1079/phn2006853. View

Wong C, Yu J . Gut microbiota in colorectal cancer development and therapy. Nat Rev Clin Oncol. 2023; 20(7):429-452. DOI: 10.1038/s41571-023-00766-x. View

Minami Y, Staples M, Giles G . The incidence of colon, breast and prostate cancer in Italian migrants to Victoria, Australia. Eur J Cancer. 1993; 29A(12):1735-40. DOI: 10.1016/0959-8049(93)90116-w. View

Nimptsch K, Wu K . Is Timing Important? The Role of Diet and Lifestyle during Early Life on Colorectal Neoplasia. Curr Colorectal Cancer Rep. 2018; 14(1):1-11. PMC: 6101255. DOI: 10.1007/s11888-018-0396-7. View

Minami Y, Miyashita M, Ishida T, Fujita M, Hamada H, Saito M . Maternal lifestyle and nutrient intakes during pregnancy and exclusive breastfeeding in relation to risk factors for breast cancer: The Japan Environment and Children's Study. Prev Med. 2023; 168:107446. DOI: 10.1016/j.ypmed.2023.107446. View

Minami Y, Tateno H . Associations between cigarette smoking and the risk of four leading cancers in Miyagi Prefecture, Japan: a multi-site case-control study. Cancer Sci. 2003; 94(6):540-7. PMC: 11160141. DOI: 10.1111/j.1349-7006.2003.tb01480.x. View

Zheng J, Liu H, Li J, Chen Y, Wei C, Shen G . Exclusive breastfeeding is inversely associated with risk of childhood overweight in a large Chinese cohort. J Nutr. 2014; 144(9):1454-9. DOI: 10.3945/jn.114.193664. View

10.

Mourtakos S, Tambalis K, Panagiotakos D, Antonogeorgos G, Arnaoutis G, Karteroliotis K . Maternal lifestyle characteristics during pregnancy, and the risk of obesity in the offspring: a study of 5,125 children. BMC Pregnancy Childbirth. 2015; 15:66. PMC: 4373521. DOI: 10.1186/s12884-015-0498-z. View

11.

Landis J, Koch G . The measurement of observer agreement for categorical data. Biometrics. 1977; 33(1):159-74. View

12.

Louie J, Flood V, Hector D, Rangan A, Gill T . Dairy consumption and overweight and obesity: a systematic review of prospective cohort studies. Obes Rev. 2011; 12(7):e582-92. DOI: 10.1111/j.1467-789X.2011.00881.x. View

13.

Sisk-Hackworth L, Kelley S, Thackray V . Sex, puberty, and the gut microbiome. Reproduction. 2022; 165(2):R61-R74. PMC: 9847487. DOI: 10.1530/REP-22-0303. View

14.

Kashtanova D, Popenko A, Tkacheva O, Tyakht A, Alexeev D, Boytsov S . Association between the gut microbiota and diet: Fetal life, early childhood, and further life. Nutrition. 2016; 32(6):620-7. DOI: 10.1016/j.nut.2015.12.037. View

15.

Mima K, Ogino S, Nakagawa S, Sawayama H, Kinoshita K, Krashima R . The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms. Surg Oncol. 2017; 26(4):368-376. PMC: 5726560. DOI: 10.1016/j.suronc.2017.07.011. View

16.

Shimizu H, Mack T, Ross R, Henderson B . Cancer of the gastrointestinal tract among Japanese and white immigrants in Los Angeles County. J Natl Cancer Inst. 1987; 78(2):223-8. View

17.

Murphy C, Lund J, Sandler R . Young-Onset Colorectal Cancer: Earlier Diagnoses or Increasing Disease Burden?. Gastroenterology. 2017; 152(8):1809-1812.e3. PMC: 5646667. DOI: 10.1053/j.gastro.2017.04.030. View

18.

Iwasaki M, Kanehara R, Yamaji T, Katagiri R, Mutoh M, Tsunematsu Y . Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan. Cancer Sci. 2021; 113(1):277-286. PMC: 8748232. DOI: 10.1111/cas.15196. View

19.

Horta B, Loret de Mola C, Victora C . Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. Acta Paediatr. 2015; 104(467):30-7. DOI: 10.1111/apa.13133. View

20.

Vandenplas Y, Carnielli V, Ksiazyk J, Luna M, Migacheva N, Mosselmans J . Factors affecting early-life intestinal microbiota development. Nutrition. 2020; 78:110812. DOI: 10.1016/j.nut.2020.110812. View