Dietary Vitamin Intake and Cancer Risk in Patients with Chronic Kidney Disease: Results from the National Health and Nutrition Examination Survey (2007-2018)

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2024 Apr 26

PMID 38668886

Authors

Jiyuan Li

Ziyi Liu

Xubiao Xie

Longkai Peng

Helong Dai

Chen Gao

Wendan Mao

Wenjia Yuan

Xue Zhao

Hongliang Zhang

Fenghua Peng

Affiliations

Soon will be listed here.

Abstract

Purpose: The relationship between vitamin intake and cancer risk in the chronic kidney disease (CKD) population is unknown. For this reason, we investigated the relationship between dietary vitamin intake and cancer risk in CKD patients and looked for effective vitamin dietary patterns.

Methods: This study included 3518 CKD patients from 2007 to 2018 National Health and Nutrition Examination Survey database. All participants were categorized into four groups based on vitamin intake by K-mean clustering. The data were collected and analyzed from June 2023 to December 2023.

Results: A total of 3518 CKD patients with a mean age of (61.8 ± 16.3) years were included in the study. During a median follow-up of 7.3 years, 137 participants died of cancer. In the multivariate adjusted cox proportional hazards model for single vitamin intake, vitamin E Q4 intake (reference Q1) reduced cancer mortality (HR (95% CI) = 0.45 (0.24-0.87), P = 0.018). Further plotting of the restricted cubic spline curve revealed a linearly decreasing relationship between vitamin E intake and cancer mortality (Poverall = 0.010 Pnon-linear = 0.163). In the multivariate adjusted cox proportional hazards model for multivitamin co-intake, the vitamin C/K intake group reduced cancer mortality compared to the low vitamin intake group (HR (95% CI) = 0.42 (0.20-0.88), P = 0.022).

Conclusion: Increased vitamin C intake was independently associated with reduced cancer risk in CKD patients, and a vitamin dietary pattern with high vitamin C/K intake was also effective in reducing cancer risk.

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