Potential Single Nucleotide Polymorphisms Markers for Radiation Dermatitis in Head and Neck Cancer Patients: A meta-analysis

Overview

Journal Strahlenther Onkol

Specialties Oncology
Radiology

Date 2024 Apr 26

PMID 38668865

Authors

Beatriz Regina Lima Aguiar

Elaine Barros Ferreira

Ana Gabriela Costa Normando

Sabrina Dos Santos Dias

Eliete Neves Silva Guerra

Paula Elaine Diniz Reis

Affiliations

Soon will be listed here.

Abstract

Purpose: To identify potential Single Nucleotide Polymorphisms (SNPs) of susceptibility for the development of acute radiation dermatitis in head and neck cancer patients, and also to verify the association between SNPs and the severity of RD.

Methods: This systematic review was reported according to the PRISMA guideline. The proportion meta-analysis was performed to identify the prevalence of genetic markers by geographical region and radiation dermatitis severity. The meta-analysis was performed to verify the association between genetic markers and RD severity. The certainty of the evidence was assessed by GRADE.

Results: Thirteen studies were included. The most prevalent SNPs were XRCC3 (rs861639) (36%), TGFβ1 (rs1800469) (35%), and RAD51 (rs1801321) (34%). There are prevalence studies in Europe and Asia, with a similar prevalence for all SNPs (29-40%). The prevalence was higher in patients who developed radiation dermatitis ≤2 for any subtype of genes (75-76%). No SNP showed a statistically significant association with very low certainty of evidence.

Conclusion: The most prevalent SNPs may be predictors of acute RD. The analysis of SNP before starting radiation therapy may be a promising method to predict the risk of developing radiation dermatitis and allow radiosensitive patients to have a customized treatment. This current review provides new research directions.

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