Altered Cortical Morphology in Major Depression Disorder Patients with Suicidality

Overview

Journal Psychoradiology

Publisher Oxford University Press

Date 2024 Apr 26

PMID 38665310

Authors

Huiru Li

Huawei Zhang

Li Yin

Feifei Zhang

Ziqi Chen

Taolin Chen

Zhiyun Jia

Qiyong Gong

Affiliations

Soon will be listed here.

Abstract

Background: Major depressive disorder (MDD) is associated with high risk of suicide, but the biological underpinnings of suicidality in MDD patients are far from conclusive. Previous neuroimaging studies using voxel-based morphometry (VBM) demonstrated that depressed individuals with suicidal thoughts or behaviors exhibit specific cortical structure alterations. To complement VBM findings, surface-based morphometry (SBM) can provide more details into gray matter structure, including the cortical complexity, cortical thickness and sulcal depth for brain images.

Objective: This study aims to use SBM to investigate cortical morphology alterations to obtain evidence for neuroanatomical alterations in depressed patients with suicidality.

Methods: Here, 3D T1-weighted MR images of brain from 39 healthy controls, 40 depressed patients without suicidality (patient controls), and 39 with suicidality (suicidal groups) were analyzed based on SBM to estimate the fractal dimension, gyrification index, sulcal depth, and cortical thickness using the Computational Anatomy Toolbox. Correlation analyses were performed between clinical data and cortical surface measurements from patients.

Results: Surface-based morphometry showed decreased sulcal depth in the parietal, frontal, limbic, occipital and temporal regions and decreased fractal dimension in the frontal regions in depressed patients with suicidality compared to both healthy and patient controls. Additionally, in patients with depression, the sulcal depth of the left caudal anterior cingulate cortex was negatively correlated with Hamilton Depression Rating Scale scores.

Conclusions: Depressed patients with suicidality had abnormal cortical morphology in some brain regions within the default mode network, frontolimbic circuitry and temporal regions. These structural deficits may be associated with the dysfunction of emotional processing and impulsivity control. This study provides insights into the underlying neurobiology of the suicidal brain.

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References

Gautam P, Anstey K, Wen W, Sachdev P, Cherbuin N . Cortical gyrification and its relationships with cortical volume, cortical thickness, and cognitive performance in healthy mid-life adults. Behav Brain Res. 2015; 287:331-9. DOI: 10.1016/j.bbr.2015.03.018. View

Fettes P, Schulze L, Downar J . Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness. Front Syst Neurosci. 2017; 11:25. PMC: 5406748. DOI: 10.3389/fnsys.2017.00025. View

Selimbegovic L, Chatard A . The mirror effect: self-awareness alone increases suicide thought accessibility. Conscious Cogn. 2013; 22(3):756-64. DOI: 10.1016/j.concog.2013.04.014. View

Lopez-Castroman J, Jaussent I, Beziat S, Guillaume S, Baca-Garcia E, Genty C . Increased severity of suicidal behavior in impulsive aggressive patients exposed to familial adversities. Psychol Med. 2014; 44(14):3059-68. DOI: 10.1017/S0033291714000646. View

Desikan R, Segonne F, Fischl B, Quinn B, Dickerson B, Blacker D . An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006; 31(3):968-80. DOI: 10.1016/j.neuroimage.2006.01.021. View

Wagner G, Koch K, Schachtzabel C, Schultz C, Sauer H, Schlosser R . Structural brain alterations in patients with major depressive disorder and high risk for suicide: evidence for a distinct neurobiological entity?. Neuroimage. 2010; 54(2):1607-14. DOI: 10.1016/j.neuroimage.2010.08.082. View

Craig A . How do you feel--now? The anterior insula and human awareness. Nat Rev Neurosci. 2008; 10(1):59-70. DOI: 10.1038/nrn2555. View

Dombrovski A, Siegle G, Szanto K, Clark L, Reynolds C, Aizenstein H . The temptation of suicide: striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression. Psychol Med. 2011; 42(6):1203-15. PMC: 3368587. DOI: 10.1017/S0033291711002133. View

Hercher C, Canetti L, Turecki G, Mechawar N . Anterior cingulate pyramidal neurons display altered dendritic branching in depressed suicides. J Psychiatr Res. 2009; 44(5):286-93. DOI: 10.1016/j.jpsychires.2009.08.011. View

10.

Rolls E . A biased activation theory of the cognitive and attentional modulation of emotion. Front Hum Neurosci. 2013; 7:74. PMC: 3600537. DOI: 10.3389/fnhum.2013.00074. View

11.

Yotter R, Nenadic I, Ziegler G, Thompson P, Gaser C . Local cortical surface complexity maps from spherical harmonic reconstructions. Neuroimage. 2011; 56(3):961-73. DOI: 10.1016/j.neuroimage.2011.02.007. View

12.

van Heeringen K, Wu G, Vervaet M, Vanderhasselt M, Baeken C . Decreased resting state metabolic activity in frontopolar and parietal brain regions is associated with suicide plans in depressed individuals. J Psychiatr Res. 2016; 84:243-248. DOI: 10.1016/j.jpsychires.2016.10.011. View

13.

Turetsky B, Crutchley P, Walker J, Gur R, Moberg P . Depth of the olfactory sulcus: a marker of early embryonic disruption in schizophrenia?. Schizophr Res. 2009; 115(1):8-11. PMC: 2757489. DOI: 10.1016/j.schres.2009.09.005. View

14.

Lutz P, Mechawar N, Turecki G . Neuropathology of suicide: recent findings and future directions. Mol Psychiatry. 2017; 22(10):1395-1412. DOI: 10.1038/mp.2017.141. View

15.

Peng H, Wu K, Li J, Qi H, Guo S, Chi M . Increased suicide attempts in young depressed patients with abnormal temporal-parietal-limbic gray matter volume. J Affect Disord. 2014; 165:69-73. DOI: 10.1016/j.jad.2014.04.046. View

16.

Ding Y, Lawrence N, Olie E, Cyprien F, Le Bars E, Bonafe A . Prefrontal cortex markers of suicidal vulnerability in mood disorders: a model-based structural neuroimaging study with a translational perspective. Transl Psychiatry. 2015; 5:e516. PMC: 4445751. DOI: 10.1038/tp.2015.1. View

17.

Nock M, Borges G, Bromet E, Alonso J, Angermeyer M, Beautrais A . Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. Br J Psychiatry. 2008; 192(2):98-105. PMC: 2259024. DOI: 10.1192/bjp.bp.107.040113. View

18.

Shah C, Zhang W, Xiao Y, Yao L, Zhao Y, Gao X . Common pattern of gray-matter abnormalities in drug-naive and medicated first-episode schizophrenia: a multimodal meta-analysis. Psychol Med. 2016; 47(3):401-413. DOI: 10.1017/S0033291716002683. View

19.

King R, Brown B, Hwang M, Jeon T, George A . Fractal dimension analysis of the cortical ribbon in mild Alzheimer's disease. Neuroimage. 2010; 53(2):471-9. PMC: 2942777. DOI: 10.1016/j.neuroimage.2010.06.050. View

20.

Chen J, Yao Z, Qin J, Yan R, Hua L, Lu Q . Aberrant Global and Regional Topological Organization of the Fractional Anisotropy-weighted Brain Structural Networks in Major Depressive Disorder. Chin Med J (Engl). 2016; 129(6):679-89. PMC: 4804414. DOI: 10.4103/0366-6999.178002. View