Changes in Adipose Tissue and Circulating Concentrations of Persistent Organic Pollutants in Midlife Women

Overview

Journal Environ Health (Wash)

Publisher American Chemical Society

Date 2024 Apr 25

PMID 38660427

Authors

Amelia Grant-Alfieri

Amila Devasurendra

Stuart Batterman

Carrie Karvonen-Gutierrez

Sung Kyun Park

Affiliations

Soon will be listed here.

Abstract

Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are persistent organic pollutants (POPs) that bioaccumulate in adipose tissue. We investigated the relationship between change in central adiposity and changes in circulating concentrations of POPs over a 12-year period during the midlife. Serum concentrations of 34 PCBs and 19 OCPs were measured at four time points (1999/2000, 2002/03, 2005/06, 2009/11) in a cohort of midlife women, the Study of Women's Health Across the Nation. Linear mixed models were used to test the association between a change in waist circumference and a change in serum POP concentrations. Sixty-five women contributed 181 PCB observations. Fifty-nine women contributed 151 OCP observations. After adjustment for covariates (study site, race and ethnicity, age at baseline, parity), a one-inch (2.54 cm) increase in the change in waist circumference between visits was associated with a 4.9% decrease in the change in serum concentration of PCB 194 (95% CI: -8.0%, -1.6%). No associations were observed for other PCB congeners or the presence of OCPs. An increase in the difference in waist circumference over time was not associated with a change in the difference in serum concentrations of PCBs and OCPs except for PCB 194, possibly due to the high lipophilicity.

Citing Articles

Associations of serum persistent organic pollutant concentrations with incident diabetes in midlife women: The Study of Women's Health Across the Nation Multi-Pollutant Study.

Grant-Alfieri A, Herman W, Watkins D, Batterman S, Karvonen-Gutierrez C, Park S Environ Res. 2024; 260():119582.

PMID: 38992756 PMC: 11656409. DOI: 10.1016/j.envres.2024.119582.

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