Treatment of Malignant Airway Obstruction with Y-shape Sigma Stent Loaded with I Seeds Installed Via Rigid Bronchoscopy

Overview

Journal BMC Pulm Med

Publisher Biomed Central

Specialty Pulmonary Medicine

Date 2024 Apr 24

PMID 38658897

Authors

Chunlong Lin

Hesong Huang

Lixia Song

Xixi Zhao

Jialing Zeng

Lun Li

Qilong Ge

Rui Li

Zhiyuan Wu

Affiliations

Soon will be listed here.

Abstract

Purpose: To summarize and analyze the safety and efficacy of a Y-shape Sigma stent loaded with I in patients with inoperable malignant main airway obstruction.

Methods: This study was approved by the Institutional Ethics Committee, and a written informed consent was obtained from each participant. A Y-shape Sigma stent loaded with I was placed under vision from rigid bronchoscopy. The primary endpoint was alleviation of symptoms and improvement of Karnofsky Performance Status (KPS) score, and the secondary endpoint was complications and technical success.

Results: From November 2018 through June 2023, total 33 patients with malignant airway obstruction were palliatively treated by installing Y-shape Sigma stents loaded with I. The airway lumen was immediately restored and the average airway opening significantly increased to 70 ± 9.4% after the procedure from baseline 30.2 ± 10.5% (p < 0.05). Average KPS score was improved from baseline 30.0 ± 10.0 to 70.0 ± 10.0 (p < 0.05) as well as PaO from baseline 50.1 ± 15.4 mmHg to 89.3 ± 8.6 mmHg (p < 0.05). The technical success rate of placing the stent in this study was 73%, and adverse events or complications including bleeding, I loss, and airway infection occurred during or after the procedure.

Conclusion: Placement of Y-shape Sigma stents under vision from rigid bronchoscopy in the patients with malignant airway obstruction is feasible and it immediately alleviates dyspnea and significantly improves quality of life.

Citing Articles

Advances in studies on tracheal stent design addressing the related complications.

Chen S, Du T, Zhang H, Zhang Y, Qiao A Mater Today Bio. 2024; 29:101263.

PMID: 39399242 PMC: 11467681. DOI: 10.1016/j.mtbio.2024.101263.

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