Inhibition of Autophagy Antagonizes Breast Cancer Brain Metastogenesis and Augments the Anticancer Activity of Lapatinib
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Citing Articles
Carew J, Espitia C, Sureshkumar S, Carrera Espinoza M, Gamble M, Wang W Cancer Lett. 2025; 613:217496.
PMID: 39892703 PMC: 11832319. DOI: 10.1016/j.canlet.2025.217496.
Targeting autophagy: a promising approach for the treatment of breast cancer brain metastases.
Nawrocki S, Espitia C, Carrera Espinoza M, Gamble M, Sureshkumar S, Chang M Clin Transl Discov. 2024; 4(4).
PMID: 39100646 PMC: 11296565. DOI: 10.1002/ctd2.340.
References
1.
Palmieri D, Bronder J, Herring J, Yoneda T, Weil R, Stark A
. Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. Cancer Res. 2007; 67(9):4190-8.
DOI: 10.1158/0008-5472.CAN-06-3316.
View
2.
Patel R, Mehta M
. Targeted therapy for brain metastases: improving the therapeutic ratio. Clin Cancer Res. 2007; 13(6):1675-83.
DOI: 10.1158/1078-0432.CCR-06-2489.
View
3.
Nawrocki S, Han Y, Visconte V, Przychodzen B, Espitia C, Phillips J
. The novel autophagy inhibitor ROC-325 augments the antileukemic activity of azacitidine. Leukemia. 2019; 33(12):2971-2974.
PMC: 7462348.
DOI: 10.1038/s41375-019-0529-2.
View
4.
Lin N, Guo H, Yap J, Mayer I, Falkson C, Hobday T
. Phase II Study of Lapatinib in Combination With Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Clinical Outcomes and Predictive Value of Early [18F]Fluorodeoxyglucose Positron Emission.... J Clin Oncol. 2015; 33(24):2623-31.
PMC: 4534525.
DOI: 10.1200/JCO.2014.60.0353.
View
5.
Bartman C, Weilandt D, Shen Y, Lee W, Han Y, TeSlaa T
. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature. 2023; 614(7947):349-357.
PMC: 10288502.
DOI: 10.1038/s41586-022-05661-6.
View