Are Depression and Poor Sleep Quality a Major Problem in Turkish Women Receiving Chemotherapy for Breast Cancer?

Overview

Journal Rev Assoc Med Bras (1992)

Specialty General Medicine

Date 2024 Apr 24

PMID 38656011

Authors

Mahmut Buyuksimsek

Ahmet Gulmez

Okan Pirinci

Mert Tohumcuoglu

Mehmet Mutlu Kidi

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study was to evaluate depression and sleep quality in Turkish women receiving neoadjuvant or adjuvant chemotherapy for breast cancer and investigate their relationship.

Methods: This cross-sectional, descriptive, and analytical study included 183 patients who received chemotherapy for non-metastatic breast cancer. Data were collected using the Beck Depression Inventory-II, the Pittsburgh Sleep Quality Index, and a disease-related/sociodemographic information form.

Results: The mean age of the participants was 50.2 years, and 50.3% were in menopause. The mean Beck Depression Inventory-II score was 19.64±10.4. Mild depression was detected in 25.7% (n=47) of the women, and moderate or severe depression in 55.2% (n=101). The mean global score of sleep quality was found to be 8.28±2.62, and the majority of the participants (79.7%, n=146) had poor sleep quality. There was a positive correlation (p<0.001, r=0.43) between depression and sleep quality scores. While a negative correlation was found between depression scores and age (p<0.001, r=0.26), the surgical procedure performed did not significantly affect depression scores (p=0.705). Additionally, depression scores were positively correlated with sleep duration (p<0.001, r=0.42) and sleep latency (p=0.01, r=0.48).

Conclusion: Very high rates of depression and poor sleep quality were detected among Turkish women receiving neoadjuvant or adjuvant chemotherapy for breast cancer. The entire healthcare team involved in the treatment process should take this relationship into consideration and use the necessary preventive and therapeutic methods.

References

Fox R, Ancoli-Israel S, Roesch S, Merz E, Mills S, Wells K . Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy. Support Care Cancer. 2019; 28(2):845-855. PMC: 6959513. DOI: 10.1007/s00520-019-04834-w. View

Wang Y, Gorenstein C . Psychometric properties of the Beck Depression Inventory-II: a comprehensive review. Braz J Psychiatry. 2014; 35(4):416-31. DOI: 10.1590/1516-4446-2012-1048. View

Fiorentino L, Rissling M, Liu L, Ancoli-Israel S . The Symptom Cluster of Sleep, Fatigue and Depressive Symptoms in Breast Cancer Patients: Severity of the Problem and Treatment Options. Drug Discov Today Dis Models. 2011; 8(4):167-173. PMC: 3228259. DOI: 10.1016/j.ddmod.2011.05.001. View

Izci F, Ilgun A, Findikli E, Ozmen V . Psychiatric Symptoms and Psychosocial Problems in Patients with Breast Cancer. J Breast Health. 2017; 12(3):94-101. PMC: 5351486. DOI: 10.5152/tjbh.2016.3041. View

Gonzalez B, Lu Q . Sleep disturbance among Chinese breast cancer survivors living in the USA. Support Care Cancer. 2018; 26(6):1695-1698. PMC: 5924438. DOI: 10.1007/s00520-018-4128-y. View

Sadaqa D, Farraj A, Naseef H, Alsaid H, Al-Shami N, Abukhalil A . Risk of developing depression among breast cancer patients in Palestine. BMC Cancer. 2022; 22(1):295. PMC: 8935763. DOI: 10.1186/s12885-022-09420-8. View

Gomes da Cunha J, Goncalves R, Silva F, Aguiar F, Mota B, Chequim B . Validation of the Residual Cancer Burden Index as a prognostic tool in women with locally advanced breast cancer treated with neoadjuvant chemotherapy. J Clin Pathol. 2021; 76(4):239-243. DOI: 10.1136/jclinpath-2021-207771. View

Park E, Gelber S, Rosenberg S, Seah D, Schapira L, Come S . Anxiety and Depression in Young Women With Metastatic Breast Cancer: A Cross-Sectional Study. Psychosomatics. 2018; 59(3):251-258. PMC: 5935568. DOI: 10.1016/j.psym.2018.01.007. View

Otte J, Davis L, Carpenter J, Krier C, Skaar T, Rand K . Sleep disorders in breast cancer survivors. Support Care Cancer. 2016; 24(10):4197-205. DOI: 10.1007/s00520-016-3247-6. View

10.

Wei M, Guo L, Zhu Y, Guo Y, Yv S, Namassevayam G . Type C Personality and Depression Among Newly Diagnosed Breast Cancer Patients: The Mediating Role of Sense of Coherence. Neuropsychiatr Dis Treat. 2020; 15:3519-3529. PMC: 6935278. DOI: 10.2147/NDT.S230278. View

11.

Fafouti M, Paparrigopoulos T, Zervas Y, Rabavilas A, Malamos N, Liappas I . Depression, anxiety and general psychopathology in breast cancer patients: a cross-sectional control study. In Vivo. 2010; 24(5):803-10. View

12.

Buysse D, Reynolds 3rd C, Monk T, BERMAN S, Kupfer D . The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989; 28(2):193-213. DOI: 10.1016/0165-1781(89)90047-4. View

13.

Turhal N, Dane F, Sinav H, Yalcin N, Khorshidi Z, Zeynep-Yalcin Z . Anxiety and depression in Turkish breast cancer patients. J BUON. 2011; 15(4):720-5. View

14.

Soares Junior J, Mota B, Nobrega G, Filassi J, Sorpreso I, Baracat E . Breast cancer survivals and hormone therapy: estrogen and melatonin. Rev Assoc Med Bras (1992). 2023; 69(10):e6910EDI. PMC: 10547489. DOI: 10.1590/1806-9282.6910EDI. View

15.

Maass S, Roorda C, Berendsen A, Verhaak P, de Bock G . The prevalence of long-term symptoms of depression and anxiety after breast cancer treatment: A systematic review. Maturitas. 2015; 82(1):100-8. DOI: 10.1016/j.maturitas.2015.04.010. View

16.

Boing L, Soares Pereira G, Araujo C, Sperandio F, Loch M, Bergmann A . Factors associated with depression symptoms in women after breast cancer. Rev Saude Publica. 2019; 53:30. PMC: 6474749. DOI: 10.11606/S1518-8787.2019053000786. View

17.

Wu H, Li F, Zhang F . The efficacy of mindfulness-based stress reduction standard or usual care in patients with breast cancer: a systematic review and meta-analysis of randomized controlled trials. Transl Cancer Res. 2022; 11(11):4148-4158. PMC: 9745358. DOI: 10.21037/tcr-22-2530. View

18.

Vegunta S, Kuhle C, Vencill J, Lucas P, Mussallem D . Sexual Health after a Breast Cancer Diagnosis: Addressing a Forgotten Aspect of Survivorship. J Clin Med. 2022; 11(22). PMC: 9698007. DOI: 10.3390/jcm11226723. View

19.

Zhang C, Hu G, Biskup E, Qiu X, Zhang H, Zhang H . Depression Induced by Total Mastectomy, Breast Conserving Surgery and Breast Reconstruction: A Systematic Review and Meta-analysis. World J Surg. 2018; 42(7):2076-2085. DOI: 10.1007/s00268-018-4477-1. View

20.

Vaughn C, Freudenheim J, Nie J, Sucheston-Campbell L, Wactawski-Wende J, Marian C . Sleep and Breast Cancer in the Western New York Exposures and Breast Cancer (WEB) Study. J Clin Sleep Med. 2017; 14(1):81-86. PMC: 5734898. DOI: 10.5664/jcsm.6886. View